LLM Mart Basic

Guide for integrating GTEx tissue expression data with ENCODE regulatory elements. Use when users need to check if a gene is expressed in a tissue, correlate regulatory elements with expression, or validate ENCODE findings against GTEx. Trigger on: GTEx, tissue expression, gene e

Guide for integrating NHGRI-EBI GWAS Catalog associations with ENCODE regulatory data. Use when users need to find GWAS variants in ENCODE peaks, connect regulatory elements to disease associations, or prioritize functional variants using ENCODE annotations. Trigger on: GWAS, gen

Build comprehensive chromatin contact maps by aggregating Hi-C loop calls (BEDPE) across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "what regions are in 3D contact in my tissue?" by creating a union catalog of chromatin loops. Handles resolut

Build comprehensive histone mark maps by aggregating narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is this histone mark present in my tissue?" by combining peak calls from multiple studies into a union peak set with

Plan and execute integrative analysis combining multiple ENCODE experiments for cross-dataset or multi-omic workflows. Use when the user wants to combine experiments, perform cross-dataset comparison, multi-omic integration, peak overlap analysis, differential binding, signal cor

Guide for using JASPAR transcription factor binding profiles with ENCODE ChIP-seq data. Use when users need to find TF binding motifs in ENCODE peaks, validate ChIP-seq targets with known motifs, or scan regulatory regions for TF binding potential. Trigger on: JASPAR, motif datab

Convert genomic coordinates between assembly versions (GRCh37/hg19 to GRCh38/hg38, mm9 to mm10). Guides UCSC liftOver for BED files, CrossMap for VCF/bigWig, and handles unmapped regions with provenance logging.

Build comprehensive DNA methylation maps by aggregating WGBS (Whole Genome Bisulfite Sequencing) data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is DNA methylated/unmethylated in my tissue?" by combining per-CpG methylation data

Guide for de novo and known motif enrichment analysis of ENCODE ChIP-seq and ATAC-seq peaks using HOMER and MEME Suite. Use when users need to discover TF binding motifs in peaks, validate ChIP-seq targets, or find co-binding partners. Trigger on: motif analysis, HOMER, MEME, de

Integrate multiple ENCODE data types (RNA-seq, ATAC-seq, Histone ChIP-seq, TF ChIP-seq) for a tissue/cell type to build a comprehensive regulatory landscape. Use when the user wants to answer "what are the enhancers, promoters, and regulatory elements active in my tissue, and whi

Guide for annotating ENCODE peaks with genomic features using ChIPseeker and GREAT. Use when users need to assign peaks to genes, determine genomic feature distribution (promoter, intron, intergenic), or perform gene ontology enrichment of peak-associated genes. Trigger on: peak

Execute ENCODE ATAC-seq processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides stage-by-stage Nextflow execution with Docker containers and cloud deployment. Handles Tn5 transposase offset correction, mitochondrial read removal, and nucleosom

Execute ENCODE ChIP-seq processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides stage-by-stage Nextflow execution with Docker containers and cloud deployment. Use when users need to process ChIP-seq data following ENCODE standards, run peak ca

Execute CUT&RUN processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing CUT&RUN or CUT&Tag data, an alternative to ChIP-seq with lower background. Trigger on: CUT&RUN pip

Execute ENCODE DNase-seq pipeline from FASTQ to hotspots and footprints. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing DNase-seq data, calling DNase hypersensitive sites, performing footprinting analysis. Trigger on: DN

Execute ENCODE Hi-C pipeline from FASTQ to contact matrices and loop calls. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing Hi-C data, generating contact matrices, or calling loops. Trigger on: Hi-C pipeline, chromatin co

Execute ENCODE RNA-seq pipeline from FASTQ to gene quantification and signal tracks. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing RNA-seq data with STAR alignment, RSEM/Kallisto quantification, or generating expression

Execute ENCODE Whole Genome Bisulfite Sequencing (WGBS) pipeline from FASTQ to methylation calls. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing WGBS/bisulfite-seq data, calling methylation levels, generating bedMethyl f

Assess the scientific integrity and trustworthiness of publications before relying on their findings. Use this skill whenever evaluating a paper for a workflow, citing a study, building an analysis on published methods, or when a user asks about the reliability of a study. Checks

Evaluate ENCODE experiment quality using standard metrics and audit flags. Use when the user asks about data quality, wants to filter for high-quality experiments, needs to interpret quality metrics (FRiP, NSC, RSC, NRF, IDR, TSS enrichment, fragment size), wants to understand EN

Every VM came back. The cluster did not. Declarative systems converge on config, and the datapath isn't config.

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Use MCP Inspector to connect to local or remote servers, inspect capabilities, call tools, read resources, test prompts, and diagnose failures before release.

Build an MCP server in TypeScript with focused tools, validated schemas, local and remote transports, Inspector tests, and production security controls.

An MCP server exposes tools, resources, or prompts through a standard protocol so an AI application can discover and use external capabilities.

Scan ~/.claude/plugins/heymegabyte-claude-skills/mcp-servers/*/ and emit .claude.json registration JSON for each forged MCP server. Default is dry-run; use --apply to write to ~/.claude.json.

Generate a timestamped arc retrospective from the past 7 days of git history in `~/.agentskills`.

Review ~/.claude/CLAUDE.md + rules for contradictions, stale guidance, duplication; consolidate

Panic-rollback button — reverses /migrate-all-to-hardened by restoring every MCP server from its archived original. Sequential to avoid ~/.claude.json collisions.

Batch-run all LLM eval cases in tools/evals/cases/*.json; aggregate pass/fail, cost, regression vs last run; exit nonzero in CI mode

Run golden-test eval suites against one or all MCP servers in mcp-servers/; compares actual tool responses to expected via exact-match + regex + min-count tiers; supports mock-mode so CI runs without API keys

One-line SaaS — from a description, scaffold a complete CF-native multi-tenant SaaS (Hono + D1 + Drizzle + Better Auth + Stripe + shadcn) deployed to a real URL

Unified supply-chain audit. Checks GitHub Actions SHA-pinning (`sha-pin:check`), package.json git+https deps (per `no-gitlab-megabytelabs-deps` semgrep), gitleaks scan, and trufflehog verified-only sweep. Surfaces any tag-mutable, git-URL, or secret-exposed surface. Per rules/ai-agent-security.md § Supply chain.

Run a learning pass after a major run; fold reusable lessons into global config

Summarize recent CHANGELOG.md entries for context restoration. Parses the canonical heading shape `## YYYY-MM-DD — pass-N — summary`. Filters: last N (default 10), YYYY-MM date prefix, or "today". Supports --json for machine-readable output.

Run quality-scores + token-budget + dep-graph, interpret results, flag missing budgets, orphans, and oversize skills

Apply a reusable lesson to ~/.agentskills (rules/skills/templates/commands), backup + commit + push

Generate a quarterly vendor secret-rotation calendar for all load-bearing vendors; emit .ics + ROTATIONS-DUE-NEXT-30-DAYS table; optionally create Google Calendar events

Resolve a 3CX contact or extension by email, extension, or name

Quick health check for a connected 3CX PBX

Snapshot of 3CX queue staffing and active call load

Review and triage abuse mailbox cases in Abnormal Security

Search for specific threat patterns in Abnormal Security by sender, recipient, attack type, or keywords

Triage recent email threats detected by Abnormal Security by severity and attack type

List open and overdue Alternative Payments invoices and optionally generate hosted payment links for them

MCP server for reusable prompt templates, multi-step workflow chains, and quality gates. Compose agentic workflows with an operator syntax; export as native ski…

中国股票数据基础设施，覆盖行情、研报、资金面、筹码、公告、龙虎榜、ETF/期权、舆情互动、基本面、行业板块、宏观与风险事件等核心数据。42+A股数据集，日更、自托管、MCP 原生，零注册、零 API Token

OKF (Open Knowledge Format): Durable, structured memory for AI agents. Author, validate, consume, and maintain portable knowledge bundles through an ecosystem o…

토스증권을 AI 에이전트와 터미널에서 다루는 도구. CLI 와 MCP 서버로 계좌·시세·주문은 물론 웹앱 전용 기능(수급·AI 시그널·스크리너·배당)까지, JSON·CSV 구조화 출력으로 AI 도구·자동화에 바로 연동.

Claude skills for LinkedIn. 11 Claude Code and Codex skills that write human-sounding LinkedIn posts, craft comments that get noticed, analyze your feed, and bu…

MCP server connecting AI agents to ITASCA engines (PFC, FLAC, 3DEC, MPoint, MassFlow) — run geotechnical & geomechanics simulations through natural conversation

A curated list of amazingly awesome articles, people, applications, software libraries and projects related to the knowledge management space

One local dashboard for every Claude Code, Codex, Cursor, Antigravity, and Kilo Code session on your Mac. Spawn in parallel, ship in parallel. Open source, MIT.

Building blocks for frontier OpenAI agents in Rust. Nanocodex empowers you with Codex-level performance anywhere.

The AI agent that lives in your framework/browser

Self-Programming AI Assistant. Capture, automate, and refine all your workflows.

Consider it done. The open-source AI agent that works out of the box · 想到，就能做到。开源、开箱即用的 AI Agent。

Make Any Website into CLI & Use your logged-in browser by AI agent.

ISO 24495 Plain Language skills and Claude Code plugin

Deterministic, fail-open tool routing for Hermes Agent with an optional local-model fallback.

1인 사업가 생산성 키트 — 직원 없이 49개를 자동화했고, 그중 바로 쓸 수 있는 AI 에이전트 스킬 26개(+실행 스크립트)를 공개합니다

AI Agents & MCPs & AI Workflow Automation • (~400 MCP servers for AI agents) • AI Automation / AI Agent with MCPs • AI Workflows & AI Agents • MCPs for AI Agent…

The open-source, self-hosted video conferencing software. Scalable, customizable, and with a powerful AI Meeting Agent.

Business operating system for Claude Code — 57 skills, 21 agents, smart daemon. Unified inbox (WhatsApp/Email/Slack/Telegram), autonomous PR merge, full-AWS mon…

A local-first, cross-platform Electron desktop workspace for Pi Coding Agent, with sessions, project files, browser tools, skills, plugins, and messaging integr…