LLM Mart Basic

Predict protein 3D structures with AlphaFold2 via ColabFold — MMseqs2-accelerated MSAs, monomer and AlphaFold2-Multimer complex folding, and confidence-based validation (pLDDT, pTM/ipTM, PAE). Use when folding a protein sequence or complex from FASTA, generating a predicted struc

Build, slice, concatenate, read, and write AnnData annotated data matrices (obs, var, X, layers, obsm, uns) — the scverse data STRUCTURE, not an analysis pipeline. Use when creating or wrangling .h5ad/zarr files, managing cell and gene annotations, concatenating batches, or handl

Infer gene regulatory networks (GRNs) from expression matrices using arboreto's scalable GRNBoost2 and GENIE3 tree-ensemble algorithms with Dask-distributed computation. Use when analyzing bulk or single-cell RNA-seq transcriptomics to map transcription-factor-to-target-gene regu

Manipulate biological sequences, parse FASTA/GenBank/PDB files, run phylogenetics, and access NCBI/PubMed programmatically via Biopython (Bio.SeqIO, Bio.Entrez, Bio.PDB, Bio.Blast). Use when scripting custom bioinformatics pipelines, batch-processing sequence files, automating BL

Query 40+ bioinformatics web services through one consistent Python API with bioservices (UniProt, KEGG, ChEMBL, Reactome, Ensembl, NCBI and more). Use when a workflow must hit multiple databases together, map identifiers across services, or run cross-database analyses — for quic

Runs NCBI BLAST+ 2.17.0 sequence searches from the command line: makeblastdb (with -parse_seqids), blastn/blastp/blastx/tblastn with tabular -outfmt 6/7 for parsing, correct -task choice (megablast vs blastn vs blastn-short), -taxids/-negative_taxids taxonomic scoping, and -mt_mo

Co-fold biomolecular complexes with Boltz-2, an open AlphaFold3-style model — predict protein + ligand (SMILES/CCD), protein + nucleic-acid, and multi-chain structures in one pass, with binding-affinity prediction. Use when folding a protein together with a small-molecule ligand,

Predict genome-wide functional genomics tracks from DNA sequence with Borzoi (Linder 2025) — a sequence-to-function model outputting RNA-seq, CAGE, ATAC, and ChIP coverage across long context, used to score non-coding and regulatory variant effects. Use when predicting functional

Query the CZ CELLxGENE Census (200M+ cells) programmatically via cellxgene-census and TileDB-SOMA, slicing expression by tissue, disease, or cell type and returning AnnData. Use when pulling reference single-cell RNA-seq data from the largest curated public atlas, running populat

Predict biomolecular complexes with Chai-1, an open AlphaFold3-style model that folds multi-entity assemblies (proteins, ligands, nucleic acids) from a single typed FASTA — strong on antibody–antigen and protein–ligand complexes, with optional MSA and restraint inputs. Use when p

Build and analyze genome-scale constraint-based metabolic models with COBRApy — flux balance analysis (FBA), flux variability analysis (FVA), gene and reaction knockouts, flux sampling, and SBML model I/O. Use when simulating metabolic networks, predicting growth or knockout phen

Process and visualize deep-sequencing coverage with the deepTools CLI — convert BAM to bigWig (bamCoverage), build log2 ratio tracks (bamCompare), run QC (multiBamSummary correlation, PCA, plotFingerprint), apply the ATAC-seq Tn5 shift (alignmentSieve --ATACshift), and make TSS/p

Run ESM protein language models — ESMC for embeddings and representations, ESMFold2 for structure prediction, and ESM3 for generative multimodal protein design across sequence, structure, and function — locally or through the hosted Biohub Platform API (formerly Forge). Use when

Manipulate, annotate, and render phylogenetic trees programmatically with the ETE Toolkit (ete3) — parse and edit Newick/NHX, detect duplication/speciation events, infer orthology and paralogy, query NCBI taxonomy, and export PDF/SVG figures. Use when traversing or reformatting t

Parse and write FCS (Flow Cytometry Standard) files v2.0-3.1 with FlowIO — extract event data as NumPy arrays, read $-keyword metadata and channel/parameter definitions, and convert events to CSV or pandas DataFrame. Use when loading raw .fcs flow-cytometry files, inspecting chan

Run fast one-liner queries to 20+ bioinformatics databases from the gget CLI or Python — gene info (Ensembl), BLAST, AlphaFold structures, Enrichr enrichment, and more. Use for quick interactive lookups of genes, sequences, structures, or pathways — for batch processing or advanc

Analyze and engineer protein glycosylation — scan sequences for N-glycosylation sequons (N-X-S/T), predict O-glycosylation hotspots, and reach curated glycoengineering tools (NetOGlyc, GlycoShield, GlycoWorkbench). Use when identifying or designing glycosylation sites, optimizing

Extract and preprocess tiles from whole-slide images (WSI) with histolab — OpenSlide-backed slide loading, tissue detection and masks, Random/Grid/Score tile extraction, and image/morphological filters for H&E preprocessing. Use when the user needs lightweight WSI slide preproces

Manage, annotate, and trace biological data with LaminDB, an open-source FAIR data framework that makes datasets queryable, versioned, and reproducible. Use when registering or querying biological datasets (scRNA-seq, spatial, flow cytometry), validating and curating data against

Design protein sequences around bound ligands, metals, and nucleic acids with LigandMPNN (Dauparas 2023) — inverse folding that conditions on non-protein context, so binding-pocket and metal-site residues are chosen to fit the actual ligand. Use when designing a small-molecule or

Every VM came back. The cluster did not. Declarative systems converge on config, and the datapath isn't config.

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Use MCP Inspector to connect to local or remote servers, inspect capabilities, call tools, read resources, test prompts, and diagnose failures before release.

Build an MCP server in TypeScript with focused tools, validated schemas, local and remote transports, Inspector tests, and production security controls.

An MCP server exposes tools, resources, or prompts through a standard protocol so an AI application can discover and use external capabilities.

Triage open Blumira findings by severity, presenting a prioritized list for review

Deep investigation of a specific Blumira finding with details, context, and comment history

MSP dashboard showing all managed accounts with open finding counts and severity breakdown

Resolve a Blumira finding with the appropriate resolution type and notes

Overall security posture review including open findings by severity, agent coverage, and trends

Run the complete CIPP M365 offboarding workflow for a departing user — capture audit state, revoke access, handle mailbox, reclaim licenses

Generate a portfolio-wide M365 security posture report — Secure Score equivalents, MFA enrollment, conditional access coverage, and domain authentication across all managed tenants

Find tenants that have drifted from the MSP's configured CIPP standards baseline — missing standards, standards in Report-only mode, recent compliance failures

Quick health snapshot for a single tenant — BPA failures, conditional access enforcement, MFA gaps, domain authentication, standards compliance

Log a time entry (billable activity) against a Clio matter

Consolidated view of one Clio matter — contacts, open tasks, recent activities, recent communications, and bills

Search Clio contacts by name, company, or email

Search or list Clio matters by name/client and status

Capacity forecast for cloud resources, scoped to a resource type or covering everything connected

Cloud cost anomaly and reclaimable-spend report for a given window

Full network health sweep across all connected network-monitoring tools — devices down, degraded links, and topology changes

Report control and configuration drift since the last known-good baseline for a client or the whole portfolio

Build a source-cited compliance evidence package for a client against a named framework

Draft evidence-backed answers to the standard cyber-insurance questionnaire for a client

List computers in ConnectWise Automate with optional filters

Your car as a chat-room agent: Raspberry Pi 5 + dashcam + local AI. CodeWatch's sibling for the garage.

The enterprise gateway for autonomous agents. Identity management, per-channel isolation, credential vault, per-session tamper-evident audit log.

AI agent for Home Assistant — talk to your home, create automations in plain language, analyze cameras with face recognition, and get proactive anomaly alerts.…

A desktop app to prototype agent ideas, inspect every harness step, replay failures, and evaluate performance, all in one place. Local-first, cloud-ready for ma…

Local-first AI memory you can see, edit, and override — portable across Claude Code, Codex, Cursor, Windsurf, and other MCP coding tools.

Web & desktop (Electron) client for the OCTO open workplace — one React + TypeScript codebase shipping browser and PC surfaces, with first-class AI agent UX.

同花顺官方 A股金融数据服务，提供股票实时行情、历史行情、财务报表、指数、板块、涨停等数据，适用于 AI Agent、量化研究和应用开发，支持 API、MCP、CLI 和 Python。Official Tonghuashun (HiThink) A-share financial data service provi…

Open-source desktop SQL workspace for PostgreSQL, MySQL/MariaDB, SQLite and 15+ more databases like DuckDB, ClickHouse, Redis and Firestore. Built-in MCP server…

🤖 Local-assist BOSS Zhipin CLI for AI agents — search, welfare filtering, shortlist, JSON-envelope output; low-risk & compliant by default.

The local-first sidebar AI agent for ComfyUI — runs on your own Claude OR ChatGPT subscription (no API keys, no extra LLM costs). Drives your live graph: edits,…

Persistent memory for Claude Code — identity, context, and continuity across sessions

🔬 A curated collection of 23,000+ agent skills for empirical research across 8 social science disciplines. | 精选 23,000+ AI Agent 技能库，覆盖8大社会科学学科的实证研究。CoPaper.AI…

A curated list of plugins, skills, MCP servers, patch/profile layers, orchestrators & UIs for DeepSeek Harness (DSH). Visualization · PPT · Coding · Agents · Lo…

World Memory Protocol.

Run your own organization of agents.

The most RAM efficient harness

AI-native, free, open-source alternative to Jira, Trello, ClickUp & Monday. Built for Scrum teams where humans and AI agents collaborate as equals — on the same…

Free open-source desktop app that scrapes JAV metadata and generates NFO + cover art for Jellyfin, Emby & Kodi. No Docker, no CLI — one-click install on Windows…

A cross-platform desktop app to manage Agent Skills in one place and sync them to multiple AI coding tools’ global skills directories — “Install once, sync ever…

天枢 (Tianshu) 是一个基于harness工程的终端编程智能体运行时（Tui X Gui），针对DeepSeek V4 做了前缀缓存工程优化（长会话实测稳态命中率 97–99%）和深度适配。它跳出了传统 AI 编程助手把大模型仅当成“工具”的局限，基于认知虚拟机 (CVM)、自感知层和信息素（Stigmergy…