LLM Mart Basic

Guide for integrating GTEx tissue expression data with ENCODE regulatory elements. Use when users need to check if a gene is expressed in a tissue, correlate regulatory elements with expression, or validate ENCODE findings against GTEx. Trigger on: GTEx, tissue expression, gene e

Guide for integrating NHGRI-EBI GWAS Catalog associations with ENCODE regulatory data. Use when users need to find GWAS variants in ENCODE peaks, connect regulatory elements to disease associations, or prioritize functional variants using ENCODE annotations. Trigger on: GWAS, gen

Build comprehensive chromatin contact maps by aggregating Hi-C loop calls (BEDPE) across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "what regions are in 3D contact in my tissue?" by creating a union catalog of chromatin loops. Handles resolut

Build comprehensive histone mark maps by aggregating narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is this histone mark present in my tissue?" by combining peak calls from multiple studies into a union peak set with

Plan and execute integrative analysis combining multiple ENCODE experiments for cross-dataset or multi-omic workflows. Use when the user wants to combine experiments, perform cross-dataset comparison, multi-omic integration, peak overlap analysis, differential binding, signal cor

Guide for using JASPAR transcription factor binding profiles with ENCODE ChIP-seq data. Use when users need to find TF binding motifs in ENCODE peaks, validate ChIP-seq targets with known motifs, or scan regulatory regions for TF binding potential. Trigger on: JASPAR, motif datab

Convert genomic coordinates between assembly versions (GRCh37/hg19 to GRCh38/hg38, mm9 to mm10). Guides UCSC liftOver for BED files, CrossMap for VCF/bigWig, and handles unmapped regions with provenance logging.

Build comprehensive DNA methylation maps by aggregating WGBS (Whole Genome Bisulfite Sequencing) data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is DNA methylated/unmethylated in my tissue?" by combining per-CpG methylation data

Guide for de novo and known motif enrichment analysis of ENCODE ChIP-seq and ATAC-seq peaks using HOMER and MEME Suite. Use when users need to discover TF binding motifs in peaks, validate ChIP-seq targets, or find co-binding partners. Trigger on: motif analysis, HOMER, MEME, de

Integrate multiple ENCODE data types (RNA-seq, ATAC-seq, Histone ChIP-seq, TF ChIP-seq) for a tissue/cell type to build a comprehensive regulatory landscape. Use when the user wants to answer "what are the enhancers, promoters, and regulatory elements active in my tissue, and whi

Guide for annotating ENCODE peaks with genomic features using ChIPseeker and GREAT. Use when users need to assign peaks to genes, determine genomic feature distribution (promoter, intron, intergenic), or perform gene ontology enrichment of peak-associated genes. Trigger on: peak

Execute ENCODE ATAC-seq processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides stage-by-stage Nextflow execution with Docker containers and cloud deployment. Handles Tn5 transposase offset correction, mitochondrial read removal, and nucleosom

Execute ENCODE ChIP-seq processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides stage-by-stage Nextflow execution with Docker containers and cloud deployment. Use when users need to process ChIP-seq data following ENCODE standards, run peak ca

Execute CUT&RUN processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing CUT&RUN or CUT&Tag data, an alternative to ChIP-seq with lower background. Trigger on: CUT&RUN pip

Execute ENCODE DNase-seq pipeline from FASTQ to hotspots and footprints. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing DNase-seq data, calling DNase hypersensitive sites, performing footprinting analysis. Trigger on: DN

Execute ENCODE Hi-C pipeline from FASTQ to contact matrices and loop calls. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing Hi-C data, generating contact matrices, or calling loops. Trigger on: Hi-C pipeline, chromatin co

Execute ENCODE RNA-seq pipeline from FASTQ to gene quantification and signal tracks. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing RNA-seq data with STAR alignment, RSEM/Kallisto quantification, or generating expression

Execute ENCODE Whole Genome Bisulfite Sequencing (WGBS) pipeline from FASTQ to methylation calls. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing WGBS/bisulfite-seq data, calling methylation levels, generating bedMethyl f

Assess the scientific integrity and trustworthiness of publications before relying on their findings. Use this skill whenever evaluating a paper for a workflow, citing a study, building an analysis on published methods, or when a user asks about the reliability of a study. Checks

Evaluate ENCODE experiment quality using standard metrics and audit flags. Use when the user asks about data quality, wants to filter for high-quality experiments, needs to interpret quality metrics (FRiP, NSC, RSC, NRF, IDR, TSS enrichment, fragment size), wants to understand EN

Every VM came back. The cluster did not. Declarative systems converge on config, and the datapath isn't config.

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Use MCP Inspector to connect to local or remote servers, inspect capabilities, call tools, read resources, test prompts, and diagnose failures before release.

Build an MCP server in TypeScript with focused tools, validated schemas, local and remote transports, Inspector tests, and production security controls.

An MCP server exposes tools, resources, or prompts through a standard protocol so an AI application can discover and use external capabilities.

List recent meetings and voice memos. Use when the user asks "what meetings did I have", "show my recent recordings", "any meetings today", "list my voice memos", or wants an overview of their meeting history. Also use when they need to find a specific meeting by browsing rather than searching.

Act as the user's live meeting sidekick inside the current terminal agent session. Use when the user explicitly asks you, the terminal agent, to watch a meeting, follow the live transcript, answer during the call, offer strategist thoughts, silently watch for risks, or track decisions. Do not use this skill to start or control the separate Minutes Coach HUD; explicit Coach or HUD lifecycle requests belong to minutes-copilot, and an ambiguous request such as "coach me live" requires one short surface clarification.

Self-coaching analysis of your own behavior across meetings — talk-time ratio, filler words, hedging language, monologue length, energy patterns, and (when meetings are tagged via /minutes-tag) what your behavior in winning meetings looks like vs losing ones. Use this whenever the user says "how did I do", "review my last meeting", "mirror", "self-review", "show my patterns", "coach me", "where am I weak", "talk time", "am I improving", "what do I do in meetings I win", "feedback on me", or asks for any kind of personal feedback on their own meeting behavior. This is the rare skill that gives the user a mirror to their own habits — surface it whenever they show curiosity about their own performance, even if they don't use the word "mirror".

Add a note to the current recording or annotate a past meeting. Use whenever the user says "note that", "remember this", "mark this as important", "add a note about", "annotate the meeting", or wants to capture a thought during or after a recording. Plain text input — no markdown needed.

Interactive meeting preparation — builds a relationship brief and talking points before a call. Use when the user says "prep me for my call with", "I'm meeting with X", "prepare me for", "what should I bring up with", "meeting prep", "get ready for my call", or wants to review history with someone before a meeting.

Generate a daily digest of today's policy-authorized meetings and voice memos — key decisions, action items, and themes across available recordings. Use when the user asks "recap my day", "what happened in my meetings today", "daily summary", "what did I discuss today", "any action items from today", or wants a consolidated view of the day's conversations.

Start or stop recording a meeting, call, or voice memo. Use this whenever the user says "record", "start recording", "capture this meeting", "stop recording", "I'm in a meeting", "take notes on this call", or wants to transcribe live audio. Also use when they ask about recording status or want to know if something is being recorded.

Draft user-facing Minutes release notes for a version from the commit range, recent GitHub releases, and the repository release checks. Use when the user asks to write, generate, prepare, revise, or review release notes or a changelog for a Minutes version.

Search past meeting transcripts and voice memos for specific topics, people, decisions, or ideas. Use this whenever the user asks "what did we discuss about X", "find that meeting where we talked about Y", "what did Alex say", "did we decide on", "what was that idea about", or any question that could be answered by searching their meeting history. Also use for "do I have any notes about" or "check my meetings for".

Guided first-time setup for Minutes — download whisper model, create directories, configure audio input. Use when the user says "set up minutes", "install minutes", "first time setup", "configure minutes", "get started with minutes", "how do I start using minutes", or when verify shows missing components.

Lightweight outcome tagging for meetings — won, lost, stalled, great, or noise. Use whenever the user says "tag this meeting", "mark that as a win", "that one was a loss", "tag yesterday's call as stalled", "mark this great", "that meeting was noise", "label that meeting", or any time they describe a meeting outcome in passing. Tagging takes 5 seconds and unlocks /minutes-mirror correlation analysis — the more meetings get tagged, the smarter mirror gets at telling the user what behavior patterns lead to wins. Surface this skill any time the user mentions a meeting result, win, loss, or wasted time.

Verify that Minutes is properly set up and working — model downloaded, mic accessible, directories exist, no stale state. Use when the user says "is minutes working", "check my setup", "verify minutes", "test recording setup", "why isn't minutes working", "minutes health check", or after running setup for the first time.

Analyze a product walkthrough, bug report video, Loom, or ScreenPal using Minutes transcription plus visual review. Use when the user wants a recorded demo or bug clip turned into a durable brief with transcript, key frames, issues, and next steps.

Weekly meeting synthesis — themes, decision arcs, stale commitments, and what deserves your attention next week. Use when the user says "weekly review", "what happened this week", "weekly summary", "recap my week", "any outstanding items", "week in review", or at the end of a work week.

Fast non-interactive briefing before any meeting — auto-detects your next calendar event, pulls relationship history, surfaces open commitments, and produces a one-page brief in under 30 seconds. Use this whenever the user says "brief me", "give me a quick brief", "what's coming up", "background on my next call", "who am I meeting next", "brief me on Sarah", "I have a call in 10 min", "quick rundown", or right before walking into a meeting. Different from /minutes-prep — brief is the fast hook-fireable version that doesn't ask questions and doesn't set goals. Use brief when speed matters; use prep when the user wants to think hard about goals first.

Manage old recordings — find large files, archive old meetings, delete processed originals. Use when the user says "clean up recordings", "how much space are meetings using", "delete old recordings", "archive meetings", "manage meeting storage", or asks about disk space from minutes.

Start and control Minutes Coach, the separate real-time copilot HUD, with an explicit meeting goal. Use only for explicit Coach or HUD lifecycle requests such as "start Minutes Coach", "open the Coach HUD", "pause Minutes Coach", "resume Minutes Coach", "Minutes Coach status", or "stop Minutes Coach". Do not use for requests that explicitly ask the current terminal agent to watch or strategize; those belong to minutes-live-sidekick. An ambiguous request such as "coach me live" requires one short surface clarification and must not automatically start Coach.

Post-meeting debrief — analyzes what happened, compares outcomes to your prep intentions, tracks decision evolution. Use when the user says "debrief", "what just happened in that meeting", "what did we decide", "debrief that call", "post-meeting", "what changed", or right after stopping a recording.

Policy-safe relationship rankings, commitments, aliases, person profiles, and topic research. Always use Minutes' bounded native CLI surfaces; never build or read a durable graph cache.

Surface recent voice memos and ideas captured from any device. Use when the user asks "what ideas did I have?", "what were my recent memos?", "what did I record while walking?", or wants to recall a captured thought.

Ultra-lightweight, open-source, self-hosted personal AI agent framework in Python with WebUI, tools, memory, MCP, multi-agent workflows, automation, and chat ap…

Governance framework for AI coding agents. It runs them through a five-step workflow (plan, build, review, test, ship) where no step counts as done without evid…

Ultimate Multi-Agent OS for Autonomous AI NPCs 2026

Personal AI Agent Hub 2026 — Build Your 24/7 Autonomous Assistant

Proven 2026 Multi-Agent AI Review System – Verdict-Driven Quality Control

Slash API Batch: Cut AI Costs by 50% in 2026

Web dashboard for Hermes Agent — multi-platform AI chat, session management, scheduled jobs, usage analytics

Agent Skills for Solopreneurs

AirLLM dramatically reduces inference memory usage, letting 70B large language models run on a single 4GB GPU card

Zero, your trustworthy AI teammate for real work.

一套 DSH runtime，Desktop、Web 与 TUI 三种开发体验。

Open-source operational advisor for ClickHouse — real-time monitoring plus AI-driven index/partition/materialized-view recommendations.

⚙️ TypeScript Style Guide and Agent Skill. A concise set of conventions and best practices for consistent, maintainable code.

Framework for AI agents to build and maintain a digital brain through Obsidian wiki

Apache Maka (Incubating) is a local-first AI agent workspace. Model messages, tool calls, tool results, permission decisions, and termination events are recorde…

Neo.mjs is a self-evolving software organism: a professional end-to-end AI engineering team whose cross-model swarm inhabits live apps via Neural Link, Active H…

Agentic development harness for Claude Code — SPEC-driven plan/run/sync, TRUST 5 quality gates, model+effort routing, and Claude×GLM multi-LLM cost control. Sin…

NocoBase is an open-source AI + no-code platform for building business systems fast. Instead of generating everything from scratch, AI works on top of productio…

An open-source AI coding agent that lives in your terminal.

PawWork — free, open-source desktop AI agent for macOS and Windows. Alternative to Codex App and Claude Cowork. BYOK with 75+ providers, ChatGPT OAuth, local mo…