LLM Mart Basic

Analyze Hacker News thread sentiment from a provided HN thread URL.

Automates browser interactions for web testing, form filling, screenshots, and data extraction. Use when the user needs to navigate websites, interact with web pages, fill forms, take screenshots, test web applications, or extract information from web pages.

Write clean, readable Pythonic code. Use this skill any time you write or change a Python file.

Predict protein 3D structures with AlphaFold2 via ColabFold — MMseqs2-accelerated MSAs, monomer and AlphaFold2-Multimer complex folding, and confidence-based validation (pLDDT, pTM/ipTM, PAE). Use when folding a protein sequence or complex from FASTA, generating a predicted struc

Build, slice, concatenate, read, and write AnnData annotated data matrices (obs, var, X, layers, obsm, uns) — the scverse data STRUCTURE, not an analysis pipeline. Use when creating or wrangling .h5ad/zarr files, managing cell and gene annotations, concatenating batches, or handl

Infer gene regulatory networks (GRNs) from expression matrices using arboreto's scalable GRNBoost2 and GENIE3 tree-ensemble algorithms with Dask-distributed computation. Use when analyzing bulk or single-cell RNA-seq transcriptomics to map transcription-factor-to-target-gene regu

Manipulate biological sequences, parse FASTA/GenBank/PDB files, run phylogenetics, and access NCBI/PubMed programmatically via Biopython (Bio.SeqIO, Bio.Entrez, Bio.PDB, Bio.Blast). Use when scripting custom bioinformatics pipelines, batch-processing sequence files, automating BL

Query 40+ bioinformatics web services through one consistent Python API with bioservices (UniProt, KEGG, ChEMBL, Reactome, Ensembl, NCBI and more). Use when a workflow must hit multiple databases together, map identifiers across services, or run cross-database analyses — for quic

Runs NCBI BLAST+ 2.17.0 sequence searches from the command line: makeblastdb (with -parse_seqids), blastn/blastp/blastx/tblastn with tabular -outfmt 6/7 for parsing, correct -task choice (megablast vs blastn vs blastn-short), -taxids/-negative_taxids taxonomic scoping, and -mt_mo

Co-fold biomolecular complexes with Boltz-2, an open AlphaFold3-style model — predict protein + ligand (SMILES/CCD), protein + nucleic-acid, and multi-chain structures in one pass, with binding-affinity prediction. Use when folding a protein together with a small-molecule ligand,

Predict genome-wide functional genomics tracks from DNA sequence with Borzoi (Linder 2025) — a sequence-to-function model outputting RNA-seq, CAGE, ATAC, and ChIP coverage across long context, used to score non-coding and regulatory variant effects. Use when predicting functional

Query the CZ CELLxGENE Census (200M+ cells) programmatically via cellxgene-census and TileDB-SOMA, slicing expression by tissue, disease, or cell type and returning AnnData. Use when pulling reference single-cell RNA-seq data from the largest curated public atlas, running populat

Predict biomolecular complexes with Chai-1, an open AlphaFold3-style model that folds multi-entity assemblies (proteins, ligands, nucleic acids) from a single typed FASTA — strong on antibody–antigen and protein–ligand complexes, with optional MSA and restraint inputs. Use when p

Build and analyze genome-scale constraint-based metabolic models with COBRApy — flux balance analysis (FBA), flux variability analysis (FVA), gene and reaction knockouts, flux sampling, and SBML model I/O. Use when simulating metabolic networks, predicting growth or knockout phen

Process and visualize deep-sequencing coverage with the deepTools CLI — convert BAM to bigWig (bamCoverage), build log2 ratio tracks (bamCompare), run QC (multiBamSummary correlation, PCA, plotFingerprint), apply the ATAC-seq Tn5 shift (alignmentSieve --ATACshift), and make TSS/p

Run ESM protein language models — ESMC for embeddings and representations, ESMFold2 for structure prediction, and ESM3 for generative multimodal protein design across sequence, structure, and function — locally or through the hosted Biohub Platform API (formerly Forge). Use when

Manipulate, annotate, and render phylogenetic trees programmatically with the ETE Toolkit (ete3) — parse and edit Newick/NHX, detect duplication/speciation events, infer orthology and paralogy, query NCBI taxonomy, and export PDF/SVG figures. Use when traversing or reformatting t

Parse and write FCS (Flow Cytometry Standard) files v2.0-3.1 with FlowIO — extract event data as NumPy arrays, read $-keyword metadata and channel/parameter definitions, and convert events to CSV or pandas DataFrame. Use when loading raw .fcs flow-cytometry files, inspecting chan

Run fast one-liner queries to 20+ bioinformatics databases from the gget CLI or Python — gene info (Ensembl), BLAST, AlphaFold structures, Enrichr enrichment, and more. Use for quick interactive lookups of genes, sequences, structures, or pathways — for batch processing or advanc

Analyze and engineer protein glycosylation — scan sequences for N-glycosylation sequons (N-X-S/T), predict O-glycosylation hotspots, and reach curated glycoengineering tools (NetOGlyc, GlycoShield, GlycoWorkbench). Use when identifying or designing glycosylation sites, optimizing

Fourteen posts of being wrong in production, compressed to checkboxes

Healthy nodes, a quiet network, 300 restarts in three days, and a latency budget measured in milliseconds

Discovery worked. Ping worked. Every TCP connection timed out, and later the tunnel only worked when someone had a terminal open.

Every VM came back. The cluster did not. Declarative systems converge on config, and the datapath isn't config.

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Record the present state by mode — decision (ADR, RFC, rule), code (spec, doc, guide, scenario), or research (a ready report or one external material); a gate picks the document type.

First-time Archcore setup — wire host configs, measure the authored context, compose the full first-day seed in one preview, and create it on one confirm; import converts CLAUDE.md, AGENTS.md, rule files, ADRs, and docs into native documents; refresh adds new facts or drills into one domain.

Plan a feature or initiative through a computed route — a small fix exits with no documents, one capability gets a spec and a plan, a large initiative gets an umbrella PRD with one spec per capability; start with sdd, sources (market research), iso (regulated work), or research (technical investigation) to run that path directly.

Review branch changes against Archcore docs, or report project health; drift runs staleness detection, deep a full documentation audit, closeout closes a finished feature, experience captures a repeated pattern.

Verify that citations actually exist and that the claims they support are faithful to the cited source. Runs deterministic existence checks (Crossref / OpenAlex / Semantic Scholar / arXiv) plus a claim-faithfulness pass via the alterlab-citation-verifier skill.

Run a systematic, reproducible literature review on a topic and return an APA 7.0 annotated bibliography with a documented search strategy. Invokes the alterlab-deep-research pipeline in lit-review mode.

Run a full multi-perspective peer review of a manuscript, simulating an Editor-in-Chief plus three peer reviewers and a Devil's Advocate, and produce a structured editorial decision and revision roadmap. Invokes the alterlab-paper-reviewer skill.

Orchestrate the end-to-end academic research-to-publication workflow (research, write, integrity check, review, revise, re-review, finalize) with mandatory integrity gates and two-stage peer review. Invokes the alterlab-research-pipeline orchestrator.

Audit infra security: secrets, deps, CI/CD, webhooks, AI/skill files

Audit Solana program code for exploitable bugs and write a findings report

Compare per-instruction CU with the stored baseline to catch regressions

Build the web client (Next.js, Vite, React) and check env, types and bundle

Build Solana programs (Anchor, Pinocchio, native), incl. verifiable builds

Build the Unity project in batchmode for WebGL, desktop, Android or PSG1

Turn a solana-ai-kit fork into a project: set up CLAUDE.md, remove kit files

Un-ignore and commit the kit config dir, instruction file, .mcp.json and .gitmodules

Replay a user's failing transaction on forked state and map the error to source

Deploy a program to devnet, or to mainnet after the user's explicit go-ahead

Review the branch diff for Solana security issues, CU waste and AI slop

Read-only check of toolchain and kit config, with one fix-it command per failure

Your efficient agentic AI coding CLI assistant

AI coding with Aegis governance built into execution: baseline-aware changes, evidence-backed delivery. Free desktop client, your choice of model. 将哲科思维融入 AI 开发…

Android in docker solution with noVNC supported, video recording, mcp server and AI-agent

Your AI assistant, built for the agentic era. Open source and local: talk to it, and it runs your agents, your coding CLIs, your browser and your apps. Windows,…

Verifiable program-level self-evolution for AI-for-Science agents: Skills and typed Operators grow from replay-verified executions.

Let Claude Code and other coding agents drive and debug Chrome from the shell. DOM, network, console and raw CDP as short commands, no screenshots and no MCP ne…

Unofficial, agent-friendly Mercadona shopping CLI (Go) — search products, read prices, build a cart and prepare checkout from the terminal. BYO credentials.

Local-first AI canvas for visual workflows, AI short drama, image/video generation, storyboarding and asset management. ComfyUI, AI agents, MCP & Blender. 本地优先…

Let any AI coding tool — Claude Code, Cursor, Codex — drive your real Chrome. One-prompt setup, muscle memory, local-first.

runs anywhere. uses anything

Open-source dots for the web: an AI agent with its own browser, one that does not get blocked.

Free MIT AI coding agent — no API key needed. Built-in free model, or bring Claude, GPT, Gemini, DeepSeek, Ollama +50 more. Swarm mode, 40+ tools, browser & des…

Open-source AI customer support system. AI-first support, human-ready operations.

A durable, multiplayer, mobile-first web app for Pi agents, built on Pi Durable

Embedded Cypher knowledge graph for Python and Rust. Bundled MCP server, describe() schema, and code-graph parser for LLM agents.

Turn PDFs, books and papers into interactive learning webpages｜将复杂材料转化为可追溯、可测验、可做笔记的学习网页

PhysicsOS 是一个面向初高中物理学习的公益可视化智能体，通过 AI 理解题目并结合物理引擎，将抽象物理过程转化为可交互、可观察、可计算、可验证的真实物理场景。

Open-source, self-hosted alternative to OpenAI Dots, Meta Muse, Grok Bot, Manus Cue and Claude Cowork. AI agents, each with a virtual machine on your PC with a…

Quant infrastructure for AI agents — a free, open-source desktop workspace for macOS and Windows where your Claude Code or Codex turns a trading idea into a bac…

Build stateful agent workflows with typed outputs, reusable tools, session forks, and ordinary TypeScript.