LLM Mart Basic

Guide for annotating ENCODE regulatory variants with ClinVar clinical significance. Use when users need to check if variants in ENCODE peaks have clinical associations, find pathogenic variants in regulatory regions, or assess variant clinical impact. Trigger on: ClinVar, clinica

Compare ENCODE experiments across different biosamples, tissues, or cell lines to identify tissue-specific regulatory patterns. Use when the user wants cross-tissue comparison, cell-type comparison, tissue-specific elements, differential chromatin, biosample matching, disease vs

Cross-reference ENCODE data with PubMed, bioRxiv, ClinicalTrials.gov, Open Targets, GTEx, ClinVar, GWAS Catalog, gnomAD, Ensembl, and other scientific databases. Use when the user wants to find publications, preprints, or clinical trials related to ENCODE experiments, chain ENCOD

Use ENCODE functional genomics data for disease mechanism research. Use when the user wants to connect GWAS variants to regulatory elements, annotate disease-associated loci with functional data, identify therapeutic targets from epigenomic data, build disease regulatory models,

Download ENCODE genomics files (BED, FASTQ, BAM, bigWig, etc.) to the user's machine. Use when the user wants to download data files from ENCODE experiments.

Query the Ensembl REST API for regulatory feature annotations, variant effect prediction (VEP), coordinate liftover, gene lookups, and cross-references. Use when the user needs to annotate variants with VEP (consequence, CADD, REVEL, SpliceAI), check Ensembl Regulatory Build over

Build comprehensive epigenomic profiles for tissues or cell types using ENCODE data. Use when the user wants to characterize chromatin states, assemble histone modification panels, create epigenomic landscapes, run ChromHMM segmentation, identify super-enhancers or bivalent domai

Analyze ENCODE functional genomics screens including CRISPR screens, MPRA (Massively Parallel Reporter Assays), and STARR-seq. Find screen data in ENCODE, process results, identify functional elements, and integrate with epigenomic annotations.

Search, query, and cross-reference NCBI GEO (Gene Expression Omnibus) datasets with ENCODE experiments. Use when the user wants to find GEO accessions for ENCODE experiments, search GEO for complementary datasets, download GEO metadata or series matrices, cross-reference ENCODE a

Query gnomAD (Genome Aggregation Database) for population allele frequencies, gene constraint scores, and variant annotations to interpret ENCODE regulatory variants. Use when the user needs allele frequencies for variants in ENCODE regulatory elements, wants to assess gene const

Guide for integrating GTEx tissue expression data with ENCODE regulatory elements. Use when users need to check if a gene is expressed in a tissue, correlate regulatory elements with expression, or validate ENCODE findings against GTEx. Trigger on: GTEx, tissue expression, gene e

Guide for integrating NHGRI-EBI GWAS Catalog associations with ENCODE regulatory data. Use when users need to find GWAS variants in ENCODE peaks, connect regulatory elements to disease associations, or prioritize functional variants using ENCODE annotations. Trigger on: GWAS, gen

Build comprehensive chromatin contact maps by aggregating Hi-C loop calls (BEDPE) across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "what regions are in 3D contact in my tissue?" by creating a union catalog of chromatin loops. Handles resolut

Build comprehensive histone mark maps by aggregating narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is this histone mark present in my tissue?" by combining peak calls from multiple studies into a union peak set with

Plan and execute integrative analysis combining multiple ENCODE experiments for cross-dataset or multi-omic workflows. Use when the user wants to combine experiments, perform cross-dataset comparison, multi-omic integration, peak overlap analysis, differential binding, signal cor

Guide for using JASPAR transcription factor binding profiles with ENCODE ChIP-seq data. Use when users need to find TF binding motifs in ENCODE peaks, validate ChIP-seq targets with known motifs, or scan regulatory regions for TF binding potential. Trigger on: JASPAR, motif datab

Convert genomic coordinates between assembly versions (GRCh37/hg19 to GRCh38/hg38, mm9 to mm10). Guides UCSC liftOver for BED files, CrossMap for VCF/bigWig, and handles unmapped regions with provenance logging.

Build comprehensive DNA methylation maps by aggregating WGBS (Whole Genome Bisulfite Sequencing) data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is DNA methylated/unmethylated in my tissue?" by combining per-CpG methylation data

Guide for de novo and known motif enrichment analysis of ENCODE ChIP-seq and ATAC-seq peaks using HOMER and MEME Suite. Use when users need to discover TF binding motifs in peaks, validate ChIP-seq targets, or find co-binding partners. Trigger on: motif analysis, HOMER, MEME, de

Integrate multiple ENCODE data types (RNA-seq, ATAC-seq, Histone ChIP-seq, TF ChIP-seq) for a tissue/cell type to build a comprehensive regulatory landscape. Use when the user wants to answer "what are the enhancers, promoters, and regulatory elements active in my tissue, and whi

Fourteen posts of being wrong in production, compressed to checkboxes

Healthy nodes, a quiet network, 300 restarts in three days, and a latency budget measured in milliseconds

Discovery worked. Ping worked. Every TCP connection timed out, and later the tunnel only worked when someone had a terminal open.

Every VM came back. The cluster did not. Declarative systems converge on config, and the datapath isn't config.

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Generate requirements from goal and research

Run or re-run research phase for current spec

Smart entry point that detects if you need a new spec or should resume existing

Show all specs and their current status

Switch active spec

Generate implementation tasks from design

Decompose a large feature into multiple dependency-aware specs (epic triage)

Check for or install a verified Tree Ring Memory CLI update without changing installation scope

This directory contains the command implementations for the fast-agent CLI.

They operate it without you.

Promised, measured, accepted. A number nobody signed is claimed, not delivered.

Prepare the meeting. One page from the record.

Find the receipt. A dated line, or it did not happen.

Diagnose trust. Process gap, or they stopped trusting you.

Generate, convert, and maintain animated GitHub-safe Markdown documents with animated SVG diagrams. Covers four SVG patterns (architecture flow, lifecycle loop, field carousel, timeline phases), guided interview for any doc type (README, architecture guide, runbook, API reference, tutorial, RFC, post-mortem, how-it-works, or custom), converting existing plain Markdown, diffing for stale diagrams, quality auditing, local preview, and multi-platform export. Use when asked to "create a README for X", "write an architecture doc", "animate this guide", "convert my doc to animated", "check if my diagrams are stale", or "export my doc for Confluence".

AWS profile management for MCP servers — discover profiles across SSO, Granted, and assumed-role chains, check credential TTL, switch profiles across VS Code and Claude Code MCP configs, and scan AWS Organization accounts.

Structured guidance for AWS CloudFront distributions, WAF web ACLs, Lambda@Edge, CloudFront Functions, Firewall Manager multi-account enforcement, and IAM/IRSA patterns. Covers OAC, cache policies, security headers, managed rule groups, rate limiting, FMS FIRST/MIDDLE/LAST ownership model, and production-ready Terraform generation.

Azure identity (Workload Identity, OIDC, Entra ID), resource tagging, AKS platform patterns, RBAC scoping, and production-readiness review — with Terraform generation.

Design, run, and debug Chaos Engineering experiments on Kubernetes using Litmus Chaos v3 and Chaos Mesh v2. Covers fault injection (pod-delete, network-loss, CPU stress, node-drain), steady-state hypothesis probes, GameDay runbooks, scheduled experiments, DORA feedback loop, and RBAC setup. Use when asked to "inject a pod fault", "run a GameDay", "schedule chaos experiments", or "debug why my ChaosEngine is stuck".

Bootstrap Checkov on a developer laptop, run static or plan-level Terraform security scanning for AWS/Azure/GCP/EKS, resolve private GitHub modules via gh CLI, generate pre-commit hooks, produce multi-format output (cli/json/sarif/junit), and fix violations with AI-generated patches. Use when asked to "scan my Terraform", "run checkov", "check my IaC for security issues", "set up checkov pre-commit", or "fix checkov findings".

Paper trading simulator for Polymarket — built for AI agents. MCP server, live order books, strategy backtesting. Install: npx clawhub install polymarket-paper-…

An SSH tool dedicated to addressing all pain points · (macOS/Windows/Linux/Android/iOS)

The first AI agent harness native to the browser. A browser extension that runs a full agent loop where you already work: it drives your tabs, spins up sandboxe…

SmartLabel AI 2026: Auto-Annotate Any Object via LLM-Powered Prompt Parsing

Local-first visual generation runtime and studio for people and coding agents, with reproducible image and video workflows across multiple providers.

Scholar All-In-One: A research infrastructure for AI agents

Give your AI agent a real browser — with a human in the loop. Open-source MCP-native browser agent.

同花顺免费开源AI插件FQGate-agent（原插件名 tonghuasun-agent）：为 Codex、Claude Code、DeepSeek 等 AI 工具提供本机 A 股实时行情、K 线、Level-2、资讯、账户查询与可选交易能力。

A non-linear AI agent workbench — session is a tree: branch anytime, and context follows the branch

Production-grade AutoCAD MCP server for AI agents — 122 tools, dual COM (live AutoCAD) + headless ezdxf engines, ISO GD&T and dimension-tolerance validation for…

A DeepSeek coding agent harness: persistent shell, Ultra subagents, auto approval, Chrome MCP and session telemetry

Waku Waku! Waku Agent is a local-first AI agent harness you actually own, including loop, memory, eval, all in code built to stay legible as it grows.

Remote control for Claude Code, Codex, Grok, and Cursor on Mac or PC. View sessions, send tasks, and drive them remotely from your phone, PIN, or Ring. OpenClaw…

Next-gen AI-native server ops panel with an in-workspace SRE agent. Crash self-healing, safe rollbacks, Docker/game servers, and local Ollama support.

Professional cloud architecture diagrams with official AWS, Azure and GCP icons, from Terraform code or a plain JSON graph. MCP server + agent skill.

A ready-to-use self-growing desktop AI assistant for long-running tasks, memory, agents, tool reviews, MCP, and high-concurrency workspace automation. / 开箱即用的自我…

Collection of templates using the Alchemyst AI Platform for your next big AI app.

Fast, exact LLM decoding on Apple Silicon (MLX) behind an OpenAI-compatible endpoint

The open source AI research agent.

Open-source agent-native visual production workspace where humans and coding agents edit the same live canvas — local-first, BYOK image/video models.