LLM Mart Basic

Analyze Neuropixels 1.0/2.0 extracellular electrophysiology with SpikeInterface — load SpikeGLX/Open Ephys recordings, preprocess and motion-correct, run Kilosort4 spike sorting, compute quality metrics, apply Allen/IBL curation, and do AI-assisted visual inspection. Use when wor

Runs FASTQ-to-VCF germline and somatic variant calling via the Nextflow nf-core/sarek pipeline pinned to -r 3.10.0 — builds the samplesheet.csv (patient, sex, status, sample, lane, fastq_1, fastq_2), runs bwa-mem/bwa-mem2/dragmap alignment plus GATK4 MarkDuplicates and BQSR again

Run full computational-pathology workflows with PathML — whole-slide-image (WSI) analysis across 160+ slide formats, multiplexed immunofluorescence (CODEX, Vectra, MERFISH), nucleus segmentation/classification (HoVer-Net, HACTNet), tissue- and cell-graph construction, HDF5 datase

Build phylogenetic trees end-to-end from raw sequences — MAFFT multiple sequence alignment, optional TrimAl trimming, IQ-TREE 3 maximum-likelihood inference with model selection and bootstraps, FastTree for large datasets, then visualize with ETE3 or FigTree. Use when reconstruct

Design protein sequences for a fixed backbone with ProteinMPNN (Dauparas 2022) — message-passing inverse folding that outputs sequences predicted to fold to a given structure, with fixed positions, tied/symmetric chains, amino-acid bias, and a soluble-model variant. Use when inve

Run differential gene expression analysis on bulk RNA-seq count matrices with PyDESeq2, the Python port of DESeq2 — size-factor normalization, dispersion estimation, Wald tests, FDR (Benjamini-Hochberg) correction, and volcano/MA plots. Use when identifying differentially express

Build complete mass-spectrometry workflows with pyOpenMS — feature detection, peptide identification, protein quantification, and full LC-MS/MS pipelines across many MS file formats (mzML, mzXML) and algorithms. Use for comprehensive proteomics and MS data processing — for simple

Read and write genomic alignment and variant files in Python with pysam (htslib bindings) — SAM/BAM/CRAM alignments, VCF/BCF variants, and FASTA/FASTQ sequences, plus region extraction and per-base coverage/pileup. Use when scripting NGS data-processing pipelines that parse, filt

Runs 16S/ITS amplicon (microbiome) analysis with the QIIME 2 distribution (2026.7; the "amplicon" distribution was renamed "qiime2" in 2026.4) in the correct order: manifest import, cutadapt trim-paired primer removal BEFORE dada2 denoise-paired (trunc-len chosen from the demux q

Generate de-novo protein backbones with RFdiffusion (Watson 2023) — a diffusion model for unconditional monomer generation, motif scaffolding, binder design against a target, and symmetric oligomers. Use when generating a new protein backbone from scratch, scaffolding a functiona

Quantifies bulk RNA-seq transcript abundance with salmon 2.x (the Rust rewrite; selective alignment or --sketch) and kallisto (v0.52.0, kb-python workflow), builds a decoy-aware gentrome index, runs quant with --gcBias -l A, then imports estimates via tximport/tximeta with a tx2g

Run the standard single-cell RNA-seq analysis pipeline with Scanpy on AnnData — QC filtering, normalization, dimensionality reduction (PCA, UMAP, t-SNE), Leiden/Louvain clustering, marker/differential expression, PAGA trajectories, and plotting. Use when analyzing scRNA-seq data

Apply the scGPT single-cell foundation model (Cui 2024) to annotate and embed cells — zero-shot and fine-tuned cell-type annotation, gene/cell embeddings, batch integration, and gene-regulatory / perturbation inference from AnnData. Use when annotating cell types with a pretraine

Run RNA velocity analysis with scVelo on single-cell RNA-seq data — estimate cell-state transitions from spliced/unspliced mRNA dynamics, infer trajectory direction, compute latent time, and identify driver genes. Use when adding directionality to trajectories or studying differe

Train deep generative models for single-cell omics with scvi-tools — probabilistic batch correction and integration (scVI), reference-mapping transfer learning (scArches), differential expression with uncertainty, and multimodal models (totalVI for CITE-seq, MultiVI for multiome)

Analyzes spatial transcriptomics with squidpy (1.8.x) on AnnData and SpatialData objects, routing platforms correctly: Visium spots use spatial_neighbors(coord_type='grid') and pair with deconvolution, while Xenium/MERFISH single-cell data use coord_type='generic'/Delaunay neighb

Store and query genomic variant data at scale with TileDB-VCF — ingest VCF/BCF into compressed TileDB arrays, add samples incrementally, run fast parallel region/sample queries, and export back to VCF. Use when managing population-genomics variant datasets that are too large for

Wraps RDKit in a high-level, pandas-friendly datamol interface with sensible defaults for everyday drug discovery — SMILES/SDF loading into DataFrames, molecule standardization, descriptors, fingerprints, Butina clustering, 3D conformer generation, scaffold analysis, and parallel

Runs molecular machine learning with DeepChem — diverse featurizers, pre-built MoleculeNet benchmark datasets, and pre-trained models (ChemBERTa, GROVER) for property prediction (ADMET, toxicity, solubility) via traditional ML or graph neural networks. Use when running end-to-end

Predicts protein-ligand binding poses with DiffDock diffusion-based molecular docking from PDB structures and SMILES, producing pose confidence scores for virtual screening and structure-based drug design. Use when docking ligands into a protein, generating binding poses, or scre

Every VM came back. The cluster did not. Declarative systems converge on config, and the datapath isn't config.

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Use MCP Inspector to connect to local or remote servers, inspect capabilities, call tools, read resources, test prompts, and diagnose failures before release.

Build an MCP server in TypeScript with focused tools, validated schemas, local and remote transports, Inspector tests, and production security controls.

An MCP server exposes tools, resources, or prompts through a standard protocol so an AI application can discover and use external capabilities.

Audit agents spawned in the current/last run against the agent-selection taxonomy

Run the Agent Diversity Review gate and emit the result table

Meta-analyze the effectiveness of a /loop arc — per-iteration metrics, LOC delta trend, saturation detection, and a keep/lengthen/delete recommendation.

Audit the rules/ directory for missing foundational principles; output gap list with priority and justification

Validate ~/.claude/settings.json hooks block — event names, file existence, executability, matcher syntax; --fix repairs common issues

Catch Resend-class bug (isError: false on HTTP 4xx/5xx) across all MCP server tool handlers

Healthcheck + drift detect + rotation-reminder across all MCP servers in ~/.claude/mcp-registry.json

Catch mock/live divergence in MCP eval golden tests (anti-pattern #2 from eval-mock-mode-discipline)

Catch the github-mcp class of bug — CallTools handlers that exist but are invisible to Claude because ListTools never advertises them (orphaned), or ListTools entries that have no handler (zombies)

Validate _router.md — check every referenced skill file exists; surface stale entries + orphan files; --fix prunes or stubs

List every active tool across all MCP servers and flag cross-MCP duplicates and semantic overlaps

Scaffold a new spawnable specialist agent def and register it in the agent taxonomy

Audit whether user-visible changes in the current session have matching CHANGELOG.md entries; report MISSING with suggested lines; --fix auto-appends

Repeatable pass upgrading an Angular admin dashboard into a compact black-and-cyan developer-cockpit PWA

Deploy an MCP server generated by forge-from-openapi --target=mcp-server; detect transport, deploy, smoke-test, print .claude.json snippet

Run the drift-detection checklist (incl. agent-drift signals); report + fix in-turn

Execute a PRP — TodoWrite breakdown, parallel implementation, validate every gate, deploy, prove on prod

Orchestrate the final review fan-out (integration + diversity + risk + release readiness)

Auto-generate a Claude Code skill (commands + types + client) from any OpenAPI 3.x spec URL or file path

Scaffold a complete Claude Code skill (commands + types + client) from a GraphQL endpoint or local schema file

Make any song you can imagine

Leading AI-powered video generation platform that specializes in creating hyper-realistic talking avatars

Hermes Agent is an open-source, self-improving autonomous AI agent developed by Nous Research

Kilo Code is a popular, open-source AI coding agent and "agentic engineering" platform designed to help developers build, refactor, and debug software faster

General-purpose agent in one static Go binary. ReAct loop, ACP server for IDEs, OpenAI-compatible REST API with embedded web UI, Telegram gateway, cron schedule…

Autonomous agent framework with structured memory, safety hooks, and loop management. Built by the agent that runs on it.

TSP自托管、零运维的 A 股「选股 + 监控 + 回测」量化工作台 | 基于 TickFlow 数据源 | LLM能力驱使策略定制+个股分析+复盘 | 自由接入第三方数据源与个性化扩展数据 | 个人开源 ,非TickFlow官方项目

Curated, verified Agent Skills powered by ModelStudio.

Run Claude Code, Codex, Antigravity, Cursor Agent and OpenCode as one runtime — persistent sessions, multi-agent councils, an OpenAI-compatible endpoint, an MCP…

pi had nothing (nothing), so I made something (something) — sorry mariozechner-senpai, I went ahead and lovingly soiled your pure pi for you. opinionated fork o…

A persistent workspace for development work that self-improves and continues beyond one session.

Open-source memory and context for user-aware agents: scoped memory, provenance, retrieval quality, correction, boundaries, evals, and MCP/HTTP access.

📚 A zero-dependency, git-backed micro-lesson library for AI Agents to asynchronously share and search verified debugging experience. Python stdlib only. | http…

Deterministic, local-first memory and guardrails for AI coding agents with no LLM in the hot path.

Deterministic spec-orchestration for local LLMs in the pi coding agent — drives prompts through refine→research→grill→compose→critique, with bundled web/docs/fe…

Native Safari browser automation for AI agents. 97 tools via AppleScript — zero overhead, keeps logins, runs silently in background. Drop-in alternative to Chro…

Agent OS: keep specialist agents in a hub, spin up a temporary orchestrator per task. Local-first, works with any model.

Git for agent memory. Branches, diffs, PRs, and rollback for what your agents know.

Multi-Provider AI Gateway - No personal logs by design. Model autodiscovery, Failover groups, High availability, Android companion app, and more - "Because we h…

Production-grade MCP server for MikroTik RouterOS with secure AI-native network automation.