LLM Mart Basic

Run differential gene expression analysis on bulk RNA-seq count matrices with PyDESeq2, the Python port of DESeq2 — size-factor normalization, dispersion estimation, Wald tests, FDR (Benjamini-Hochberg) correction, and volcano/MA plots. Use when identifying differentially express

Build complete mass-spectrometry workflows with pyOpenMS — feature detection, peptide identification, protein quantification, and full LC-MS/MS pipelines across many MS file formats (mzML, mzXML) and algorithms. Use for comprehensive proteomics and MS data processing — for simple

Read and write genomic alignment and variant files in Python with pysam (htslib bindings) — SAM/BAM/CRAM alignments, VCF/BCF variants, and FASTA/FASTQ sequences, plus region extraction and per-base coverage/pileup. Use when scripting NGS data-processing pipelines that parse, filt

Runs 16S/ITS amplicon (microbiome) analysis with the QIIME 2 distribution (2026.7; the "amplicon" distribution was renamed "qiime2" in 2026.4) in the correct order: manifest import, cutadapt trim-paired primer removal BEFORE dada2 denoise-paired (trunc-len chosen from the demux q

Generate de-novo protein backbones with RFdiffusion (Watson 2023) — a diffusion model for unconditional monomer generation, motif scaffolding, binder design against a target, and symmetric oligomers. Use when generating a new protein backbone from scratch, scaffolding a functiona

Quantifies bulk RNA-seq transcript abundance with salmon 2.x (the Rust rewrite; selective alignment or --sketch) and kallisto (v0.52.0, kb-python workflow), builds a decoy-aware gentrome index, runs quant with --gcBias -l A, then imports estimates via tximport/tximeta with a tx2g

Run the standard single-cell RNA-seq analysis pipeline with Scanpy on AnnData — QC filtering, normalization, dimensionality reduction (PCA, UMAP, t-SNE), Leiden/Louvain clustering, marker/differential expression, PAGA trajectories, and plotting. Use when analyzing scRNA-seq data

Apply the scGPT single-cell foundation model (Cui 2024) to annotate and embed cells — zero-shot and fine-tuned cell-type annotation, gene/cell embeddings, batch integration, and gene-regulatory / perturbation inference from AnnData. Use when annotating cell types with a pretraine

Run RNA velocity analysis with scVelo on single-cell RNA-seq data — estimate cell-state transitions from spliced/unspliced mRNA dynamics, infer trajectory direction, compute latent time, and identify driver genes. Use when adding directionality to trajectories or studying differe

Train deep generative models for single-cell omics with scvi-tools — probabilistic batch correction and integration (scVI), reference-mapping transfer learning (scArches), differential expression with uncertainty, and multimodal models (totalVI for CITE-seq, MultiVI for multiome)

Analyzes spatial transcriptomics with squidpy (1.8.x) on AnnData and SpatialData objects, routing platforms correctly: Visium spots use spatial_neighbors(coord_type='grid') and pair with deconvolution, while Xenium/MERFISH single-cell data use coord_type='generic'/Delaunay neighb

Store and query genomic variant data at scale with TileDB-VCF — ingest VCF/BCF into compressed TileDB arrays, add samples incrementally, run fast parallel region/sample queries, and export back to VCF. Use when managing population-genomics variant datasets that are too large for

Wraps RDKit in a high-level, pandas-friendly datamol interface with sensible defaults for everyday drug discovery — SMILES/SDF loading into DataFrames, molecule standardization, descriptors, fingerprints, Butina clustering, 3D conformer generation, scaffold analysis, and parallel

Runs molecular machine learning with DeepChem — diverse featurizers, pre-built MoleculeNet benchmark datasets, and pre-trained models (ChemBERTa, GROVER) for property prediction (ADMET, toxicity, solubility) via traditional ML or graph neural networks. Use when running end-to-end

Predicts protein-ligand binding poses with DiffDock diffusion-based molecular docking from PDB structures and SMILES, producing pose confidence scores for virtual screening and structure-based drug design. Use when docking ligands into a protein, generating binding poses, or scre

Computes mass-spectral similarity and identifies compounds for metabolomics with matchms — comparing mass spectra, scoring similarity (cosine, modified cosine), and searching spectral libraries to annotate unknowns. Use when matching MS/MS spectra, identifying metabolites, or lib

Applies medicinal-chemistry filters with the medchem library — drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, and molecular complexity metrics for compound prioritization and library cleanup. Use when filtering or triaging a compound library, flagging PA

Featurizes molecules for machine learning with molfeat — ECFP/MACCS/MAP4 fingerprints, RDKit and Mordred physicochemical descriptors, pharmacophore and shape descriptors, and pretrained embeddings (ChemBERTa, ChemGPT, CheMeleon) exposed as scikit-learn transformers that convert S

Queries the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biomedical relationships across genes, drugs, diseases, phenotypes, pathways, and biological processes. Use when exploring drug-disease or gene-disease links, building disease-centric knowledge subgraphs, or

Loads Therapeutics Data Commons (TDC, PyTDC) AI-ready drug-discovery datasets and benchmarks — ADME, toxicity, drug-target interaction (DTI), scaffold splits, and molecular oracles for therapeutic ML and pharmacological prediction. Use when fetching a standardized benchmark datas

Every VM came back. The cluster did not. Declarative systems converge on config, and the datapath isn't config.

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Use MCP Inspector to connect to local or remote servers, inspect capabilities, call tools, read resources, test prompts, and diagnose failures before release.

Build an MCP server in TypeScript with focused tools, validated schemas, local and remote transports, Inspector tests, and production security controls.

An MCP server exposes tools, resources, or prompts through a standard protocol so an AI application can discover and use external capabilities.

List ConnectWise CPQ quote templates available to copy

Search ConnectWise CPQ quotes by account, status, or date range

Add an internal or external note to a ConnectWise PSA ticket

View agreement status and entitlements for a company in ConnectWise PSA

Close a ConnectWise PSA ticket with resolution notes

Create a new service ticket in ConnectWise PSA

Retrieve detailed ticket information from ConnectWise PSA

Log a time entry against a ConnectWise PSA ticket

Search for configuration items (assets) in ConnectWise PSA

Create a schedule entry/appointment in ConnectWise PSA

Search for tickets in ConnectWise PSA by various criteria

Update fields on an existing ConnectWise PSA ticket

Search recent Crewhu surveys, surfacing detractors and promoters

Run the reliability scorecard for one service, or every connected service if omitted - error-budget burn rate where an SLO is defined, trend reporting otherwise

Generate the current on-call handoff brief - what's paging, what's escalated without an owner, last-shift history, and known-flaky alerts to watch

Draft a blameless postmortem for a given incident (by ID or name), or the most recent significant incident within a time window

List all devices at a Domotz-monitored site

Find a Domotz device by name, IP address, or MAC address

Overview of a Domotz site's network health

Pull full detail for one Checkpoint Harmony Email detection and the message behind it

LLM-powered toolkit for skill analysis, AI interviews, resume scoring, and job structuring. Automates professional skill taxonomy and interview processes with a…

【三年面试五年模拟】AIGC/LLM/AI Agent算法工程师面试资源平台。涵盖AIGC、LLM大模型、AI Agent、具身智能、传统深度学习、计算机视觉、自然语言处理、自动驾驶、机器学习、强化学习、大数据挖掘、世界模型、元宇宙、AGI等AI行业面试笔试干货经验与核心跨周期知识。

Easiest and laziest way for building multi-agent LLMs applications.

Drive Claude Code or OpenAI Codex from your phone — resume sessions, stream output, approve tool permissions remotely. End-to-end encrypted, zero-knowledge rela…

MCP server for autonomous agent economies: wallets, signed RTC micropayments, bounty discovery, BoTTube video publishing, and Beacon agent-to-agent messaging. G…

Free, open-source alternative to Microsoft Office with built-in AI agents — Word (.docx), Excel (.xlsx), PowerPoint (.pptx), PDF and Markdown editing for macOS,…

NSE BSE Indian Stock Market Data MCP server — search, screen & analyze all 8,200+ NSE/BSE stocks with 34 tools: live quotes, financials, technicals, 326-ratio s…

全流程 智能招投标 Agent：标书生成 · 招投标解读 · 标书检查 · 标书文档ai排版 · 商机发现 一键完成。 21 项合规检查 · 多模型切换 · RAG 知识库 · OCR 抽取。 从招标公告到可交付 docx 文档，全流程 AI 自动化。

Benzi is AI-native code intelligence infrastructure. Claude Code greps; Cursor embeds; Aider maps signatures; Benzi resolves — and answers in O(1). Every langua…

From ticket to reviewed pull request. Free and open-source, on your machine.

Get web data for AI agents and LLMs - fast, efficient, and reliable with Rust

Open-source, license-free MCP server for RTL waveform debug: reads FST waveforms (VCD/FSDB auto-convert) plus a SystemVerilog netlist, with 34 tools covering dr…

Open-source, desktop-grade AI agent that gets real work done — data analysis, slides, docs, video & web research. Built on OpenClaw; runs tools on your real des…

Parallel, isolated dev environments for humans and AI coding agents. Real containers. Real databases. Zero collisions.

OpenCode goal plugin for Codex-style goal mode, /goal slash commands, persistent objectives, and AI coding agent focus.

Battle-tested skill library for AI agents. Save 98% of API costs with ready-to-use code for crypto, PDFs, search, web scraping & more. No trial-and-error, no ex…

Deep Code 是专为 deepseek-v4 模型优化的终端 AI 编码助手，支持深度思考、推理强度控制以及 Agent Skills。

China Unicom's Yuanjing Wanwu Agent Platform is an enterprise-grade, multi-tenant AI agent development platform. It helps users build applications such as intel…

⚡ CloakBrowser MCP server for AI agents: Playwright-powered browsing, clean tool forwarding, Docker support, and multi-session HTTP transport.

MCP-NixOS - Model Context Protocol Server for NixOS resources