LLM Mart Basic

Find and work with ENCODE single-cell genomics data including scRNA-seq and scATAC-seq. Use when the user asks about single-cell experiments, cell type resolution, clustering from ENCODE data, deconvolution of bulk signals using single-cell references, or comparing single-cell vs

Track ENCODE experiments locally with publications, citations, and provenance. Use when the user wants to build a collection of experiments, manage citations, compare experiments, or track data provenance.

Query the UCSC Genome Browser REST API to retrieve regulatory tracks, DNA sequences, cCRE annotations, TF binding clusters, and track schemas for any genomic region. Use when the user wants to look up what regulatory elements exist at a genomic locus, retrieve DNA sequence under

Annotate genetic variants (GWAS hits, eQTLs, rare variants) with ENCODE functional data to interpret non-coding variation. Use when the user has variants of interest and wants to understand their regulatory context, identify causal variants from GWAS loci, assess variant impact o

Comprehensive guide for visualizing ENCODE data including deeptools heatmaps, IGV screenshots, UCSC track hubs, and publication-quality plots. Use when users need to create visualizations of ChIP-seq signal, peak landscapes, genome browser views, or any visual representation of E

Build comprehensive chromatin accessibility maps by aggregating ATAC-seq and DNase-seq narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is chromatin accessible in my tissue?" by combining peak calls into a union peak s

Guide for multi-experiment batch operations: QC screening, batch download, comparison, and report generation across many ENCODE experiments simultaneously. Use when users need to process 5+ experiments together, create experiment comparison tables, perform batch quality checks, o

Install bioinformatics tools for ENCODE data analysis. Covers CLI tools (BWA, STAR, samtools, MACS2), R/Bioconductor packages (DESeq2, Seurat, ChIPseeker), Python packages (Scanpy, deeptools), and Nextflow pipeline infrastructure. Generates conda environments, R install scripts,

Guide for integrating CellxGene Census single-cell data with ENCODE bulk experiments. Use when users need cell-type-specific expression context for ENCODE regulatory data, want to deconvolve bulk ENCODE signals, or validate regulatory elements at single-cell resolution. Trigger o

Generate proper ENCODE citations for publications, grants, and presentations. Use when the user needs to cite ENCODE data, create bibliography entries, write acknowledgment sections, or ensure compliance with ENCODE data use policy.

Guide for annotating ENCODE regulatory variants with ClinVar clinical significance. Use when users need to check if variants in ENCODE peaks have clinical associations, find pathogenic variants in regulatory regions, or assess variant clinical impact. Trigger on: ClinVar, clinica

Compare ENCODE experiments across different biosamples, tissues, or cell lines to identify tissue-specific regulatory patterns. Use when the user wants cross-tissue comparison, cell-type comparison, tissue-specific elements, differential chromatin, biosample matching, disease vs

Cross-reference ENCODE data with PubMed, bioRxiv, ClinicalTrials.gov, Open Targets, GTEx, ClinVar, GWAS Catalog, gnomAD, Ensembl, and other scientific databases. Use when the user wants to find publications, preprints, or clinical trials related to ENCODE experiments, chain ENCOD

Use ENCODE functional genomics data for disease mechanism research. Use when the user wants to connect GWAS variants to regulatory elements, annotate disease-associated loci with functional data, identify therapeutic targets from epigenomic data, build disease regulatory models,

Download ENCODE genomics files (BED, FASTQ, BAM, bigWig, etc.) to the user's machine. Use when the user wants to download data files from ENCODE experiments.

Query the Ensembl REST API for regulatory feature annotations, variant effect prediction (VEP), coordinate liftover, gene lookups, and cross-references. Use when the user needs to annotate variants with VEP (consequence, CADD, REVEL, SpliceAI), check Ensembl Regulatory Build over

Build comprehensive epigenomic profiles for tissues or cell types using ENCODE data. Use when the user wants to characterize chromatin states, assemble histone modification panels, create epigenomic landscapes, run ChromHMM segmentation, identify super-enhancers or bivalent domai

Analyze ENCODE functional genomics screens including CRISPR screens, MPRA (Massively Parallel Reporter Assays), and STARR-seq. Find screen data in ENCODE, process results, identify functional elements, and integrate with epigenomic annotations.

Search, query, and cross-reference NCBI GEO (Gene Expression Omnibus) datasets with ENCODE experiments. Use when the user wants to find GEO accessions for ENCODE experiments, search GEO for complementary datasets, download GEO metadata or series matrices, cross-reference ENCODE a

Query gnomAD (Genome Aggregation Database) for population allele frequencies, gene constraint scores, and variant annotations to interpret ENCODE regulatory variants. Use when the user needs allele frequencies for variants in ENCODE regulatory elements, wants to assess gene const

Every VM came back. The cluster did not. Declarative systems converge on config, and the datapath isn't config.

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Use MCP Inspector to connect to local or remote servers, inspect capabilities, call tools, read resources, test prompts, and diagnose failures before release.

Build an MCP server in TypeScript with focused tools, validated schemas, local and remote transports, Inspector tests, and production security controls.

An MCP server exposes tools, resources, or prompts through a standard protocol so an AI application can discover and use external capabilities.

List, search, and inspect ENCODE files by format, type, and assembly

Generate ENCODE citations for publications, grants, and presentations

Check if two ENCODE experiments are compatible for combined analysis

Cross-reference ENCODE data with PubMed, GEO, ClinicalTrials, and bioRxiv

Download ENCODE files (BED, FASTQ, BAM, bigWig) with MD5 verification

Log derived files and trace provenance back to ENCODE source data

Store, check, or clear ENCODE API credentials for restricted data

Assess ENCODE experiment quality using audit counts and replicate counts

Search ENCODE experiments by assay, organ, biosample, or target

Track ENCODE experiments locally with publications and provenance

Record the present state by mode — decision (ADR, RFC, rule), code (spec, doc, guide, scenario), or research (a ready report or one external material); a gate picks the document type.

First-time Archcore setup — wire host configs, measure the authored context, compose the full first-day seed in one preview, and create it on one confirm; import converts CLAUDE.md, AGENTS.md, rule files, ADRs, and docs into native documents; refresh adds new facts or drills into one domain.

Plan a feature or initiative through a computed route — a small fix exits with no documents, one capability gets a spec and a plan, a large initiative gets an umbrella PRD with one spec per capability; start with sdd, sources (market research), iso (regulated work), or research (technical investigation) to run that path directly.

Review branch changes against Archcore docs, or report project health; drift runs staleness detection, deep a full documentation audit, closeout closes a finished feature, experience captures a repeated pattern.

Verify that citations actually exist and that the claims they support are faithful to the cited source. Runs deterministic existence checks (Crossref / OpenAlex / Semantic Scholar / arXiv) plus a claim-faithfulness pass via the alterlab-citation-verifier skill.

Run a systematic, reproducible literature review on a topic and return an APA 7.0 annotated bibliography with a documented search strategy. Invokes the alterlab-deep-research pipeline in lit-review mode.

Run a full multi-perspective peer review of a manuscript, simulating an Editor-in-Chief plus three peer reviewers and a Devil's Advocate, and produce a structured editorial decision and revision roadmap. Invokes the alterlab-paper-reviewer skill.

Orchestrate the end-to-end academic research-to-publication workflow (research, write, integrity check, review, revise, re-review, finalize) with mandatory integrity gates and two-stage peer review. Invokes the alterlab-research-pipeline orchestrator.

Infrastructure-first security audit — secrets, supply chain, CI/CD, LLM/skill security, OWASP, STRIDE. Complements /audit-solana (program-level)

Security audit for Solana programs (Anchor/native)

Open-source super AI assistant & Agent Harness. Plans tasks, runs tools and skills, self-evolves with memory and knowledge. Multi-model, multi-channel. Lightwei…

Open-source AI browser agent for web automation: a web browsing agent and computer-use agent in plain English. Browser MCP for Claude Code and Gemini CLI.

Agent-native trading terminal built on DeepSeek Harness. Crypto, US, CN and HK in one three-column GUI, 19+ hot-swappable connectors, dry-run by default with hu…

Open-source desktop and web coding agent with a first-party host and harness, durable sessions, model connections, streaming chat, and workspace tools.

OrcaReplay — Time travel for AI agents. Record, replay, fork, and debug any agent run with any model. Built by the OrcaRouter.ai team.

A complete toolkit for connecting R and LLMs

OpenSRE — the memory-first AI SRE. Self-hosted incident investigation with episodic memory, knowledge graph, web console, Slack & Teams. opensre.in

A desktop AI coding assistant that works with your local projects. Ally helps you understand code, edit files, search a workspace, manage tasks, and complete de…

【在线免费使用】 简单快速将SQL或DBML转换为美观的ER图（支持 Agent Skill）/ The best SQL to ER Diagram converter (Support Agent Skill).

Operation-bound protection for autonomous AI agents: contain and verify operations before committing changes, understand intent and risk across long-running wor…

Local-first AI coding agent desktop: Electron + Rust host core + pi Agent Harness + user-installable plugins

Local-only Go static analysis engine with a built-in MCP server. Gives AI coding agents deterministic structural awareness: call graphs, impact analysis, symbol…

Self-hosted AI agent workspace with tool calling, MCP, multi-model routing, sandboxed execution, multi-agent workflows, and LLM-authored 3D character animation…

Automated TDD enforcement for Claude Code

High-performance platform for building websites, e-commerce, and web applications—with Native AI, JavaScript development, and a marketplace for portable sites a…

Autonomous AI-agent orchestration engine for job discovery with decision traces, tool adapters, and production-grade run control.

Token efficient Claude Code full Python rebuild. AI Coding Agent in 310K LoC Python.

OPC — One Person Company. A full team in a single Claude Code skill. Adaptive agent orchestrator with 21 built-in roles, 6 flow templates, and adversarial quali…

Open-source, secure environment with real-world tools for enterprise-grade agents.

MCP server for AI-powered GitHub project management — agent orchestration, PRD-to-issues pipeline, sprint planning, and multi-agent swarm coordination