LLM Mart Basic

Runs 16S/ITS amplicon (microbiome) analysis with the QIIME 2 distribution (2026.7; the "amplicon" distribution was renamed "qiime2" in 2026.4) in the correct order: manifest import, cutadapt trim-paired primer removal BEFORE dada2 denoise-paired (trunc-len chosen from the demux q

Generate de-novo protein backbones with RFdiffusion (Watson 2023) — a diffusion model for unconditional monomer generation, motif scaffolding, binder design against a target, and symmetric oligomers. Use when generating a new protein backbone from scratch, scaffolding a functiona

Quantifies bulk RNA-seq transcript abundance with salmon 2.x (the Rust rewrite; selective alignment or --sketch) and kallisto (v0.52.0, kb-python workflow), builds a decoy-aware gentrome index, runs quant with --gcBias -l A, then imports estimates via tximport/tximeta with a tx2g

Run the standard single-cell RNA-seq analysis pipeline with Scanpy on AnnData — QC filtering, normalization, dimensionality reduction (PCA, UMAP, t-SNE), Leiden/Louvain clustering, marker/differential expression, PAGA trajectories, and plotting. Use when analyzing scRNA-seq data

Apply the scGPT single-cell foundation model (Cui 2024) to annotate and embed cells — zero-shot and fine-tuned cell-type annotation, gene/cell embeddings, batch integration, and gene-regulatory / perturbation inference from AnnData. Use when annotating cell types with a pretraine

Run RNA velocity analysis with scVelo on single-cell RNA-seq data — estimate cell-state transitions from spliced/unspliced mRNA dynamics, infer trajectory direction, compute latent time, and identify driver genes. Use when adding directionality to trajectories or studying differe

Train deep generative models for single-cell omics with scvi-tools — probabilistic batch correction and integration (scVI), reference-mapping transfer learning (scArches), differential expression with uncertainty, and multimodal models (totalVI for CITE-seq, MultiVI for multiome)

Analyzes spatial transcriptomics with squidpy (1.8.x) on AnnData and SpatialData objects, routing platforms correctly: Visium spots use spatial_neighbors(coord_type='grid') and pair with deconvolution, while Xenium/MERFISH single-cell data use coord_type='generic'/Delaunay neighb

Store and query genomic variant data at scale with TileDB-VCF — ingest VCF/BCF into compressed TileDB arrays, add samples incrementally, run fast parallel region/sample queries, and export back to VCF. Use when managing population-genomics variant datasets that are too large for

Wraps RDKit in a high-level, pandas-friendly datamol interface with sensible defaults for everyday drug discovery — SMILES/SDF loading into DataFrames, molecule standardization, descriptors, fingerprints, Butina clustering, 3D conformer generation, scaffold analysis, and parallel

Runs molecular machine learning with DeepChem — diverse featurizers, pre-built MoleculeNet benchmark datasets, and pre-trained models (ChemBERTa, GROVER) for property prediction (ADMET, toxicity, solubility) via traditional ML or graph neural networks. Use when running end-to-end

Predicts protein-ligand binding poses with DiffDock diffusion-based molecular docking from PDB structures and SMILES, producing pose confidence scores for virtual screening and structure-based drug design. Use when docking ligands into a protein, generating binding poses, or scre

Computes mass-spectral similarity and identifies compounds for metabolomics with matchms — comparing mass spectra, scoring similarity (cosine, modified cosine), and searching spectral libraries to annotate unknowns. Use when matching MS/MS spectra, identifying metabolites, or lib

Applies medicinal-chemistry filters with the medchem library — drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, and molecular complexity metrics for compound prioritization and library cleanup. Use when filtering or triaging a compound library, flagging PA

Featurizes molecules for machine learning with molfeat — ECFP/MACCS/MAP4 fingerprints, RDKit and Mordred physicochemical descriptors, pharmacophore and shape descriptors, and pretrained embeddings (ChemBERTa, ChemGPT, CheMeleon) exposed as scikit-learn transformers that convert S

Queries the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biomedical relationships across genes, drugs, diseases, phenotypes, pathways, and biological processes. Use when exploring drug-disease or gene-disease links, building disease-centric knowledge subgraphs, or

Loads Therapeutics Data Commons (TDC, PyTDC) AI-ready drug-discovery datasets and benchmarks — ADME, toxicity, drug-target interaction (DTI), scaffold splits, and molecular oracles for therapeutic ML and pharmacological prediction. Use when fetching a standardized benchmark datas

Provides the RDKit cheminformatics toolkit for low-level, fine-grained molecular primitives — SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure/SMARTS search, 2D/3D coordinate generation, similarity, and reaction handling. Use when custom sanitization,

Drives the Rowan cloud quantum-chemistry platform via its Python API for computational chemistry — pKa prediction, geometry optimization, conformer searching, molecular property calculations, protein-ligand docking (AutoDock Vina), and AI protein cofolding (Chai-1, Boltz-1/2), wi

Builds PyTorch-native graph neural networks with TorchDrug for molecules and proteins, exposing custom GNN architectures, task/dataset abstractions, molecular generation, retrosynthesis planning, and knowledge-graph reasoning. Use when a project specifically needs TorchDrug's dat

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Use MCP Inspector to connect to local or remote servers, inspect capabilities, call tools, read resources, test prompts, and diagnose failures before release.

Build an MCP server in TypeScript with focused tools, validated schemas, local and remote transports, Inspector tests, and production security controls.

An MCP server exposes tools, resources, or prompts through a standard protocol so an AI application can discover and use external capabilities.

Treat an AI agent skill as both an instruction package and a software dependency: inspect what it says, what it runs, what it can access, and how it updates.

Triage recent email threats detected by Abnormal Security by severity and attack type

List open and overdue Alternative Payments invoices and optionally generate hosted payment links for them

Reconcile an Alternative Payments payout by listing its transactions and matching them against invoices and customers

EOL/EOS risk report — devices, OS versions, and firmware approaching or past end-of-life/end-of-support, prioritized by criticality

Forward-looking hardware refresh calendar for the given window — replace-now / plan-this-year / monitor tiers

Warranty status snapshot — expired, expiring-soon, and unknown-coverage devices for one client or the whole portfolio

Create a threshold-based monitor for an Atera agent

Create a new service ticket in Atera

Search the Atera knowledge base for articles

List active RMM alerts from Atera

Log work hours on an Atera ticket

Resolve an RMM alert in Atera

Execute a PowerShell script on an Atera agent

Search for RMM agents in Atera by customer or machine name

Search for Atera customers by name or criteria

Update fields on an existing Atera ticket

Triage open Auvik alerts, rank by severity, and recommend dismissals for known noise

Scan Auvik interface statistics for saturated links and recurring congestion

Inventory devices for an Auvik tenant with type, manage status, and lifecycle breakdown

Audit a tenant's networks, interfaces, and saved configurations; flag drift and missing backups

The fastest way to put Volcengine Ark in your terminal and your AI agent — go from prompt to generated media, multimodal answer, or deployed endpoint in a sin…

本地私有、开源的自进化跨平台 AI 内容发现 Agent：先理解你，再主动从 B站、小红书、抖音、YouTube、X、知乎、Reddit、微博等平台与开放 Web 寻找内容。（支持 deepseek harness 插件） | Local-first open-source cross-platform AI cont…

Persistent memory for AI coding agents — one verified kb_search replaces the grep/find/ls orientation loop. Cross-repo, CPU-only, zero token spend.

AI 时代的伯克希尔：基于 Claude Code / Codex 的价值投资研究框架。巴菲特·芒格·段永平·李录四大师方法论 + 多Agent并行研究。| AI-era Berkshire: a value investing research framework built for Claude Code / Co…

The batteries-included, No-Code FinOps automation platform, with the AI you trust.

Open-source 3D AI agent framework — GLB/glTF avatars with LLM brains, memory, emotions, and autonomous payments. MCP server · x402 · Solana/EVM · Three.js. Embe…

XLSX parser for LLMs, RAG, LangChain, LangGraph, CrewAI, Claude, MCP — turns Excel (.xlsx) into citation-ready JSON with formulas, charts, dependency graphs, an…

Hermes-Relay — Your Hermes AI agent, in your pocket — chat, voice, and control.

A minimalist, terminal-native coding agent written in C.

AI-powered OSINT agent with interactive REPL, MCP server, and CLI. 19 tools. Works with Claude, GPT-4, or local models. For authorized security research only.

AI pair programming in your terminal — one static binary, sub-ms startup, any model

Where data access meets operational intelligence

Build your own security agents. Open-source framework for agents with live, read-only access to your infrastructure, with no path to widen it. Reasons across AW…

Multi-workspace terminal aggregator with Claude Code AI integration

Go implementation of AI coding agent

Harness engineering beginner tutorial, from 0 to 1

Generate images directly in DeepSeek Harness chats

A smarter, self-hosted AI assistant — multi-user, multi-agent.

Turn any research paper into a commercialization report — 6 AI agents, TRL/MRL scoring, patent landscape, market intelligence, verified citations. DeepSeek / Op…

Power BI CLI - semantic models (.NET TOM) and PBIR reports for token-efficient AI agent usage, built for Claude Code