LLM Mart Basic

Build comprehensive histone mark maps by aggregating narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is this histone mark present in my tissue?" by combining peak calls from multiple studies into a union peak set with

Plan and execute integrative analysis combining multiple ENCODE experiments for cross-dataset or multi-omic workflows. Use when the user wants to combine experiments, perform cross-dataset comparison, multi-omic integration, peak overlap analysis, differential binding, signal cor

Guide for using JASPAR transcription factor binding profiles with ENCODE ChIP-seq data. Use when users need to find TF binding motifs in ENCODE peaks, validate ChIP-seq targets with known motifs, or scan regulatory regions for TF binding potential. Trigger on: JASPAR, motif datab

Convert genomic coordinates between assembly versions (GRCh37/hg19 to GRCh38/hg38, mm9 to mm10). Guides UCSC liftOver for BED files, CrossMap for VCF/bigWig, and handles unmapped regions with provenance logging.

Build comprehensive DNA methylation maps by aggregating WGBS (Whole Genome Bisulfite Sequencing) data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is DNA methylated/unmethylated in my tissue?" by combining per-CpG methylation data

Guide for de novo and known motif enrichment analysis of ENCODE ChIP-seq and ATAC-seq peaks using HOMER and MEME Suite. Use when users need to discover TF binding motifs in peaks, validate ChIP-seq targets, or find co-binding partners. Trigger on: motif analysis, HOMER, MEME, de

Integrate multiple ENCODE data types (RNA-seq, ATAC-seq, Histone ChIP-seq, TF ChIP-seq) for a tissue/cell type to build a comprehensive regulatory landscape. Use when the user wants to answer "what are the enhancers, promoters, and regulatory elements active in my tissue, and whi

Guide for annotating ENCODE peaks with genomic features using ChIPseeker and GREAT. Use when users need to assign peaks to genes, determine genomic feature distribution (promoter, intron, intergenic), or perform gene ontology enrichment of peak-associated genes. Trigger on: peak

Execute ENCODE ATAC-seq processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides stage-by-stage Nextflow execution with Docker containers and cloud deployment. Handles Tn5 transposase offset correction, mitochondrial read removal, and nucleosom

Execute ENCODE ChIP-seq processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides stage-by-stage Nextflow execution with Docker containers and cloud deployment. Use when users need to process ChIP-seq data following ENCODE standards, run peak ca

Execute CUT&RUN processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing CUT&RUN or CUT&Tag data, an alternative to ChIP-seq with lower background. Trigger on: CUT&RUN pip

Execute ENCODE DNase-seq pipeline from FASTQ to hotspots and footprints. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing DNase-seq data, calling DNase hypersensitive sites, performing footprinting analysis. Trigger on: DN

Execute ENCODE Hi-C pipeline from FASTQ to contact matrices and loop calls. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing Hi-C data, generating contact matrices, or calling loops. Trigger on: Hi-C pipeline, chromatin co

Execute ENCODE RNA-seq pipeline from FASTQ to gene quantification and signal tracks. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing RNA-seq data with STAR alignment, RSEM/Kallisto quantification, or generating expression

Execute ENCODE Whole Genome Bisulfite Sequencing (WGBS) pipeline from FASTQ to methylation calls. Child of pipeline-guide. Provides Nextflow execution with Docker and cloud deployment. Use when processing WGBS/bisulfite-seq data, calling methylation levels, generating bedMethyl f

Assess the scientific integrity and trustworthiness of publications before relying on their findings. Use this skill whenever evaluating a paper for a workflow, citing a study, building an analysis on published methods, or when a user asks about the reliability of a study. Checks

Evaluate ENCODE experiment quality using standard metrics and audit flags. Use when the user asks about data quality, wants to filter for high-quality experiments, needs to interpret quality metrics (FRiP, NSC, RSC, NRF, IDR, TSS enrichment, fragment size), wants to understand EN

Discover and characterize regulatory elements (enhancers, promoters, silencers, insulators, super-enhancers) using ENCODE data and the cCRE catalog. Use when the user wants to find candidate regulatory elements, identify active enhancers in a tissue, map promoter states, classify

Generate publication-ready methods sections, figure legends, supplementary tables, and data availability statements from ENCODE analysis provenance. Implements the scientific documentation standards requiring complete metadata reporting. Use when the user needs to write methods,

Conduct rigorous cross-study meta-analysis of scRNA-seq data from ENCODE, integrating multiple single-cell transcriptomic datasets for a tissue/cell type. Use when the user wants to answer "what cell types exist in my tissue and what genes define them?" by combining scRNA-seq dat

A surprising share of AI-in-the-terminal failures aren't the AI. They're zsh, and a version of bash from 2006.

A Claude Code plugin turns standalone project configuration into a namespaced, installable extension that teams and communities can update as one unit.

None of the safety came from the model. It came from six boring habits.

Skills package instructions and references. Subagents run work in a separate context and return results. They solve different problems and can be composed deliberately.

Six hours in, one step left, everything green, and the incident that didn't happen

CLAUDE.md carries persistent project context. Skills load reusable procedures when relevant. Separating stable facts from task-specific workflows keeps both easier to maintain.

Twenty minutes recovering secrets that never existed, and the one sentence from a human that ended it

An API request routing a model's tool call through an approval gate to a remote MCP server

31 config keys, two audits, and why the first one was wrong in both directions

The official MCP Registry stores standardized server metadata rather than package code. Publishers verify a namespace, describe installation or remote access, and submit immutable versions.

Everyone looks at the Dockerfile. The file that actually leaked the key was the project file.

Remote MCP authorization uses established OAuth standards, but secure integration still requires issuer validation, least-privilege scopes, protected token handling, and server-side enforcement.

"Copy it over and switch the reference" is two steps, and the outage lives in the one nobody checks

stdio fits local processes and prototypes. Streamable HTTP fits hosted services and shared integrations. The right choice follows where the capability runs and who must reach it.

The most important rule wasn't about what I could change. It was about what I was allowed to display.

Tools perform operations, resources expose readable context, and prompts provide reusable templates. Choosing the correct primitive makes an MCP server easier to understand and govern.

Use MCP Inspector to connect to local or remote servers, inspect capabilities, call tools, read resources, test prompts, and diagnose failures before release.

Build an MCP server in TypeScript with focused tools, validated schemas, local and remote transports, Inspector tests, and production security controls.

An MCP server exposes tools, resources, or prompts through a standard protocol so an AI application can discover and use external capabilities.

Treat an AI agent skill as both an instruction package and a software dependency: inspect what it says, what it runs, what it can access, and how it updates.

Turn a GAIA workflow misfire into a redacted, classified, filing-ready bug report in one read-only pass. Self-diagnoses config issues inline; files probable bugs upstream on confirmation.

Judge-the-form, human-gated hardening. Reviews recurring code-audit-frontend findings and, with approval, drafts the lowest-context-weight form (deterministic check / skill / path-scoped prose rule) into the working tree. Pass `list` to see live candidates or `why <finding_class>` to explain one.

Initialize a new project from the GAIA React template, renames, strips GAIA branding, configures i18n, installs Claude skills/plugins.

Plan a complex feature using GAIA's task-orchestration pattern, structures the work into fresh-context subagent phases for your approval. Does not implement.

Cut a new GAIA release, bump version, graduate CHANGELOG, regenerate manifest, open release PR, then tag on merge. Maintainer-only.

Detect and, on explicit consent, additively append the languages Serena is not indexing to the `languages:` list in `.serena/project.yml`, then prompt a Serena restart. Never mutates without a yes; inert without Serena.

Author an immutable SPEC artifact through Socratic discovery (spec-kit wrapper), then STOP. Terminal, never runs /gaia-plan; it prints a /gaia-plan prompt the human pastes into a fresh session. Pass `auto <description>` for non-interactive mode that answers its own questions.

Maintainer-only autonomous health audit + auto-heal loop. Runs N=3 fresh-team audit-fix-audit cycles with circuit breakers, reports an F-to-A+ verdict (folding in the shared Claude-integration fitness grade) or escalates.

Single post-init onboarding command; detects situation, runs only owed phases; safe to re-run. --reconfigure rotates token and re-selects tools.

GAIA before_specify hook: constitution placeholder check + spec-kit version-pin drift detection.

GAIA after_specify hook: immutability lint over the just-written SPEC artifact.

Close a plan after implementation+merge. Offers wiki-promote for the plan's consolidated SUMMARY.md, cold-consolidates an out-of-band merge, then early-reaps the local plan folder once cost is represented in cost.jsonl.

GAIA self-review: pre-gate-2 review pass on the in-progress SPEC draft.

Close a SPEC after implementation+merge. Optional drain of deferred wiki-promote, cold-consolidates an out-of-band merge into SUMMARY.md, then early-reaps the local SPEC folder once cost is represented in cost.jsonl.

GAIA Socratic discovery wrapper: /speckit-specify for the initial draft, then GAIA's own Socratic clarify loop.

GAIA before_implement hook: render PO-authored UATs into Playwright e2e specs at .playwright/e2e/spec-NNN/.

Promote merged SPEC or plan content into the GAIA wiki.

This project uses the GAIA preset. Bare `/speckit-clarify` is not the clarify path here: core clarify writes an off-shape artifact (a `## Clarifications` / `### Session` block with five-word answers) and carries a question cap GAIA does not use. Run `/gaia-spec` instead — it driv

GAIA-wrapped /speckit-specify: writes through core, then relocates the artifact to .gaia/local/specs/SPEC-NNN/SPEC.md and stamps GAIA frontmatter.

Show or configure the compact Fallow Impact statusline in Claude Code

Okou connects to the tools your team already uses and does the work — across marketing, sales, engineering, and operations, under your control.

An open-source Digital Worker platform for reliable execution, continuous co-evolution, and building Enterprise AI assets.

A curated list of AI Agent evolution, memory systems, multi-agent architectures, and self-improvement projects. | evomap.ai

A governance harness for AI coding.

DeepSeek Harness 手机版：可直接安装的 Android APK，AI 免 Root 操作手机（Shizuku/root 可选），文件编辑只需所有文件访问权限，前台保活 + AI 通知

Local-first, governed AI agent runtime for Python — embed it in your app, or run it as a CLI or ACP server. Permissions, MCP, memory and audit replay built in.

Orbi — the factory that builds and operates AI software factories. GitHub Issues in, releases and runnable system out

Open-source AI agent harness in native Rust — GUI, CLI, headless, and webapp from one binary. Multi-provider, MCP, skills, plugins, agent teams.

The SDK for browser agents. Interact, search, extract, and fetch any site reliably across the web

Agent-native shopping for extreme value: verifiable same-product price evidence, checkout, orders, delivery, and after-sales.

The extensible power-user platform for Google Antigravity. Adds a native In-App Browser, animated Desktop Pets, revamped Gemini UI, and custom BYOK Gemini Pro k…

Open-source, single-binary, self-hosted AI agent — your models and data stay on your machine. A coding agent on par with Claude Code and a personal assistant li…

Your pocket agent. Local-first AI agents on iOS and Android — real workspaces, tool execution with approvals, and your choice of model (DSH · Claude Code · Code…

Bridge between QQ (SnowLuma OneBot v11) and DeepSeek Harness agents: social simulation, safe MCP tools, slang learning and more.

A 7×6 framework for agent architecture. 28 patterns, each placed at a coordinate, runnable Python code with verified engineering slices from Claude Code, Aider,…

针对 AI 自动化渗透 Agent 的新一代反制蜜罐，通过反向代理将API密饵载入真实业务、反向提示词注入等方式反制自动化渗透 Agent，实现多款主流通用Agent的反制上线控制。

Open-source, local-first AI agent for coding and real work. BYOK models, MCP, skills, plugins, workflows, and private knowledge bases.

A free AI-agent toolbox for Android, 一站式安卓AI Agent工具箱

Google Workspace CLI — one command-line tool for Drive, Gmail, Calendar, Sheets, Docs, Chat, Admin, and more. Dynamically built from Google Discovery Service. I…

Independent, unofficial CLI to edit CapCut and JianYing (剪映) projects — subtitles, timing, speed, volume, templates, cut long-form to shorts. No API needed, rea…