{"slug":"ct-status-diff","title":"ct-status-diff","summary":"Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03). Surfaces exactly what changed on the trial registry for your coverage: New / Suspended / Withdrawn / Terminated / Recruiting / Recruitment-Complete / Completed / ","platform":"Claude","tags":[],"authorName":"LLM Mart","authorSlug":"llm-mart","score":0,"source":"github","price":null,"verified":false,"createdAt":"2026-09-15T18:28:51.198893Z","repo":{"url":"https://github.com/agentii-ai/agentii-investment-intelligence","stars":203,"forks":16,"license":"Apache-2.0","updatedAt":"2026-09-21T11:07:34Z"},"bodyHtml":"<hr>\n<p>name: ct-status-diff\ndescription: \"Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03). Surfaces exactly what changed on the trial registry for your coverage: New / Suspended / Withdrawn / Terminated / Recruiting / Recruitment-Complete / Completed / Ahead / Delayed / Upsized / Downsized, every row carrying previous and new values, with risk flags on Terminated and Downsized and re-timing flags on Ahead and Delayed. The stored-previous-value discipline makes each week's diff reproducible.\"\nsectors: [med.medicines_biotech, med.medical_devices]\nmulti_ticker_semantics: basket_v1_1\ntemporal_scope:\ndefault_quarters: 4\nmax_quarters: 8\ndescription: \"Weekly diff over the latest two snapshots by default; up to 8 quarters of diff history on request.\"\nallowed_tools:</p>\n<ul>\n<li>get_ct_status_changes</li>\n<li>search_clinical_trials</li>\n<li>get_clinical_trial</li>\n<li>search_companies</li>\n<li>get_company_profile</li>\n<li>search_investment_cases</li>\n<li>search_by_analogue</li>\n<li>search_knowledge_entries</li>\n<li>get_knowledge_entry\nretrieval_scope: structured_only\nmin_tool_diversity: 3\nparameter_free: false</li>\n</ul>\n<hr>\n<blockquote>\n<p>Methodology inspired by publicly taught clinical-trial monitoring frameworks; all text is an original paraphrase.</p>\n</blockquote>\n<h2>Defaults</h2>\n<table>\n<thead>\n<tr>\n<th>Parameter</th>\n<th>Default Value</th>\n<th>Rationale</th>\n</tr>\n</thead>\n<tbody>\n<tr>\n<td>window</td>\n<td>latest two snapshots</td>\n<td>The diff is always between consecutive stored states</td>\n</tr>\n<tr>\n<td>categories</td>\n<td>all 11</td>\n<td>Complete change report; filter on request</td>\n</tr>\n<tr>\n<td>risk_flags</td>\n<td>on</td>\n<td>Terminated / Downsized are surfaced first</td>\n</tr>\n<tr>\n<td>gap_statement</td>\n<td>on</td>\n<td>Missing snapshot weeks are stated, never inferred</td>\n</tr>\n</tbody>\n</table>\n<h2>Preflight</h2>\n<p>Run canonical pre-flight per <code>contracts/preflight.md</code>. Propagate X-Agentii-Trace per <code>contracts/x-agentii-trace-header.md</code>. Confirm the snapshot coverage via <code>get_ct_status_changes</code> before framing any readout.</p>\n<h2>Triggers</h2>\n<ul>\n<li>\"What changed on clinicaltrials.gov for my coverage this week?\"</li>\n<li>\"Which of [ticker]'s trials moved this week?\"</li>\n<li>\"Any trial delays or accelerations in my watchlist?\"</li>\n<li>\"Flag every terminated or downsized trial since last week.\"</li>\n<li>\"Did any recruitment complete for [ticker]?\"</li>\n<li>\"Show the previous and new primary-completion dates for [drug]'s program.\"</li>\n<li>\"Which trials were upsized this week?\"</li>\n<li>\"Is [trial]'s enrollment collapsing?\"</li>\n<li>\"Summarize the week's trial-registry changes for the sector.\"</li>\n<li>\"What should I re-check ahead of [readout] based on registry moves?\"</li>\n<li>\"Compare this week's diff to the month-ago diff.\"</li>\n</ul>\n<h2>Production Grounding</h2>\n<ul>\n<li>The diff is a stored-state comparison: every row pairs a NEW value with the PREVIOUS value from the prior snapshot — the previous-value column is the discipline; a row without both is a defect.</li>\n<li>The 11-category taxonomy: New / Suspended / Withdrawn / Terminated / Recruiting / Recruitment-Complete / Completed / Ahead / Delayed / Upsized / Downsized.</li>\n<li>Risk signals: Terminated and Downsized (enrollment collapse is the earliest visible distress). Re-timing alerts: Ahead / Delayed primary-completion moves.</li>\n<li>Recruitment-Complete means the readout clock has started — treat it as a catalyst-date confirmation.</li>\n<li>Gap windows: if snapshots are not consecutive archive writes, the gap is stated on the rows — a change is never attributed across a missing week.</li>\n<li>Determinism: identical snapshots yield byte-identical diffs; never invent an intermediate state.</li>\n<li>Badge discipline: <code>[FACT]</code> registry rows, <code>[DEDUCTED]</code> interpretations, <code>[VIEW]</code> positioning, with the summary table.</li>\n</ul>\n<h2>Data Source Priority</h2>\n<ol>\n<li><code>get_ct_status_changes</code> — the stored-weekly-snapshot diff (pipeline.ct_status_snapshot).</li>\n<li>Trial context: <code>search_clinical_trials</code> / <code>get_clinical_trial</code> for design and endpoints.</li>\n<li>Company context: <code>search_companies</code> / <code>get_company_profile</code>.</li>\n<li>Historical grounding: <code>search_investment_cases</code> (event_type=termination/delay/safety) + <code>search_by_analogue</code>.</li>\n<li>Knowledge: <code>search_knowledge_entries</code> for trial-judgment patterns.</li>\n</ol>\n<h2>Methodology</h2>\n<h3>Retrieval Scope</h3>\n<p>structured_only</p>\n<h3>Retrieval Strategy</h3>\n<ol>\n<li>Pull the weekly diff via <code>get_ct_status_changes</code> (ticker-filtered for single names, sector-wide for watchlists).</li>\n<li>Rank rows: risk signals first, then re-timing, then recruiting/completed, then new.</li>\n<li>For each risk-signal row, pull the trial's design via <code>get_clinical_trial</code> and state what changed and what it implies.</li>\n<li>Ground termination/delay reads in <code>search_investment_cases</code> / <code>search_by_analogue</code> (sectors=med); cite /v/ records.</li>\n<li>Attach the gap-window statement verbatim wherever the tool reports one.</li>\n</ol>\n<h3>Temporal Scope</h3>\n<p>See frontmatter temporal_scope block. Historical diff series (month-over-month) available on request.</p>\n<h3>Tool Allowlist</h3>\n<p>See frontmatter allowed_tools.</p>\n<h3>Protocol</h3>\n<ol>\n<li>Snapshot-diff pull</li>\n<li>Risk/re-timing triage</li>\n<li>Per-signal trial context</li>\n<li>Historical grounding</li>\n<li>Weekly change report + watch flags</li>\n</ol>\n<h2>Modes</h2>\n<ul>\n<li><strong>Watchlist</strong> (default): one diff report across the basket, sorted risk-first.</li>\n<li><strong>Single ticker</strong>: per-trial change ledger with trial context.</li>\n<li><strong>Signal scan</strong>: restrict to risk signals (Terminated/Downsized) or re-timing (Ahead/Delayed).</li>\n</ul>\n<h2>Tool Fallbacks</h2>\n<table>\n<thead>\n<tr>\n<th>Failure</th>\n<th>Fallback</th>\n</tr>\n</thead>\n<tbody>\n<tr>\n<td>get_ct_status_changes empty (&lt;2 snapshots)</td>\n<td>State the coverage gap: the diff needs two consecutive snapshot cycles; use search_clinical_trials metadata as a degraded view</td>\n</tr>\n<tr>\n<td>Trial not in snapshots</td>\n<td>Flag as registry-coverage gap; do not fabricate a previous value</td>\n</tr>\n<tr>\n<td>Knowledge tools empty</td>\n<td>Proceed with structured diff only; annotate knowledge coverage_gap</td>\n</tr>\n</tbody>\n</table>\n<h2>Output File</h2>\n<p><code>{ticker}/{YYYY-MM-DD_HHMM}_ct-status-diff_{affix}.md</code> (watchlist: <code>watchlist/{YYYY-MM-DD_HHMM}_ct-status-diff_{affix}.md</code>)</p>\n<h2>Output Structure</h2>\n<ol>\n<li><strong>Executive Summary</strong> — the week in trial-registry changes, 2-3 sentences</li>\n<li><strong>Risk Signals</strong> — Terminated / Downsized rows with previous/new values and trial context</li>\n<li><strong>Re-Timing Alerts</strong> — Ahead / Delayed rows with date deltas</li>\n<li><strong>Flow Changes</strong> — New / Recruiting / Recruitment-Complete / Completed / Suspended / Withdrawn rows</li>\n<li><strong>Gap Statement</strong> — snapshot windows with missing weeks stated</li>\n<li><strong>Watch Flags</strong> — what to re-check before the next readout</li>\n<li><strong>Coverage Gaps</strong> — missing snapshots, unregistered trials, degraded modes</li>\n</ol>\n<h2>Error Handling</h2>\n<table>\n<thead>\n<tr>\n<th>Error</th>\n<th>Fallback</th>\n</tr>\n</thead>\n<tbody>\n<tr>\n<td>Fewer than 2 snapshots</td>\n<td>coverage_gap with the two-cycle requirement; degraded metadata view only</td>\n</tr>\n<tr>\n<td>Empty diff</td>\n<td>State it plainly — a clean week is a valid result; never pad</td>\n</tr>\n<tr>\n<td>Ticker not in med universe</td>\n<td>Resolve via company match; surface the classification gap</td>\n</tr>\n</tbody>\n</table>\n<h2>Memory Load</h2>\n<p>See <code>contracts/memory-load.md</code>.</p>\n<h2>Snapshot</h2>\n<p>See <code>contracts/snapshot-synthesis.md</code>.</p>\n<h2>Final Summary (TUI)</h2>\n<p>Include ### Key Citations block with 0-10 clickable /v/ URLs.</p>\n<h2>References</h2>\n<ul>\n<li><code>contracts/citation-and-memory.md</code></li>\n<li><code>contracts/output-frontmatter-schema.md</code></li>\n<li><code>contracts/memory-load.md</code></li>\n<li><code>contracts/snapshot-synthesis.md</code></li>\n<li><code>contracts/preflight.md</code></li>\n<li><code>references/knowledge-frameworks.md</code></li>\n</ul>\n","files":[{"path":"references/knowledge-frameworks.md","sizeBytes":2222,"isText":true},{"path":"references/modes.md","sizeBytes":478,"isText":true},{"path":"SKILL.md","sizeBytes":7069,"isText":true}],"reviewScore":null,"reviewSummary":null,"trust":{"provenance":"trusted-source-unreviewed","notice":"Community-authored content, reproduced verbatim and not vetted as instructions. 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